Maja Lindenmeyer

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Our group represents the core facility of the “European Renal cDNA Bank-Kroener Fresenius Biopsy Bank” (ERCB-KFB), a multicenter study for gene expression analysis in different human renal diseases, and the “Hamburg and European Renal Omics Bank” (HERO), a collaborative project for conducting translational research in human renal diseases. Using state-of-the art Omics and non-Omics technologies and in collaboration with different research partners we aim to

• support the renal scientific community by translational research

• expand our knowledge of disease pathomechanisms
• define molecular disease subgroups
• identify biomarkers
• find new ways treating human renal diseases.

1: Greiten JK, Kliewe F, Schnarre A, Artelt N, Schröder S, Rogge H, Amann K, Daniel C, Lindenmeyer MT, Cohen CD, Endlich K, Endlich N. The role of filamins in mechanically stressed podocytes. FASEB J. 2021 May;35(5): e21560. doi: 10.1096/fj.202001179RR. PMID: 33860543.

2: Sachs M, Wetzel S, Reichelt J, Sachs W, Schebsdat L, Zielinski S, Seipold L, Heintz L, Müller SA, Kretz O, Lindenmeyer M, Wiech T, Huber TB, Lüllmann-Rauch R, Lichtenthaler SF, Saftig P, Meyer-Schwesinger C. ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage. J Am Soc Nephrol. 2021 Mar 30: ASN.2020081213. doi: 10.1681/ASN.2020081213. Epub ahead of print. PMID: 33785583.

3: Abed A, Leroyer AS, Kavvadas P, Authier F, Bachelier R, Foucault-Bertaud A, Bardin N, Cohen CD, Lindenmeyer MT, Genest M, Joshkon A, Jourde-Chiche N, Burtey S, Blot-Chabaud M, Dignat-George F, Chadjichristos CE. Endothelial-Specific Deletion of CD146 Protects Against Experimental Glomerulonephritis in Mice.
Hypertension. 2021 Apr;77(4):1260-1272. doi: 10.1161/HYPERTENSIONAHA.119.14176. Epub 2021 Mar 10. PMID: 33689459.

4: Lepa C, Hoppe S, Stöber A, Skryabin BV, Sievers LK, Heitplatz B, Ciarimboli G, Neugebauer U, Lindenmeyer MT, Cohen CD, Drexler HCA, Boor P, Weide T, Pavenstädt H, George B. TrkC Is Essential for Nephron Function and Trans- Activates Igf1R Signaling. J Am Soc Nephrol. 2021 Feb;32(2):357-374. doi: 10.1681/ASN.2020040424. Epub 2020 Dec 30. PMID: 33380522.

5: Faivre A, Katsyuba E, Verissimo T, Lindenmeyer M, Rajaram RD, Naesens M, Heckenmeyer C, Mottis A, Feraille E, Cippà P, Cohen C, Longchamp A, Allagnat F, Rutkowski JM, Legouis D, Auwerx J, de Seigneux S. Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease. Nephrol Dial Transplant. 2021 Jan 1;36(1):60-68. doi: 10.1093/ndt/gfaa124. PMID: 33099633.

6: Moschovaki-Filippidou F, Steiger S, Lorenz G, Schmaderer C, Ribeiro A, von Rauchhaupt E, Cohen CD, Anders HJ, Lindenmeyer M, Lech M. Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice. Int J Mol Sci. 2020 Sep 23;21(19):6978. doi: 10.3390/ijms21196978. PMID: 32977372; PMCID: PMC7583818.

7: Braun F, Lütgehetmann M, Pfefferle S, Wong MN, Carsten A, Lindenmeyer MT, Nörz D, Heinrich F, Meißner K, Wichmann D, Kluge S, Gross O, Pueschel K, Schröder AS, Edler C, Aepfelbacher M, Puelles VG, Huber TB. SARS-CoV-2 renal tropism associates with acute kidney injury. Lancet. 2020 Aug 29;396(10251):597-598. doi: 10.1016/S0140-6736(20)31759-1. Epub 2020 Aug 17. PMID: 32818439; PMCID: PMC7431179.

8: Krebs CF, Reimers D, Zhao Y, Paust HJ, Bartsch P, Nuñez S, Rosemblatt MV, Hellmig M, Kilian C, Borchers A, Enk LUB, Zinke M, Becker M, Schmid J, Klinge S, Wong MN, Puelles VG, Schmidt C, Bertram T, Stumpf N, Hoxha E, Meyer-Schwesinger C, Lindenmeyer MT, Cohen CD, Rink M, Kurts C, Franzenburg S, Koch-Nolte F, Turner JE, Riedel JH, Huber S, Gagliani N, Huber TB, Wiech T, Rohde H, Bono MR, Bonn S, Panzer U, Mittrücker HW. Pathogen-induced tissue-resident memory TH17 (TRM17) cells amplify autoimmune kidney disease. Sci Immunol. 2020 Aug 7;5(50): eaba4163. doi: 10.1126/sciimmunol.aba 4163. PMID: 32769171.

9: Ma Q, Honarpisheh M, Li C, Sellmayr M, Lindenmeyer M, Böhland C, Romagnani P, Anders HJ, Steiger S. Soluble Uric Acid Is an Intrinsic Negative Regulator of Monocyte Activation in Monosodium Urate Crystal-Induced Tissue Inflammation. J Immunol. 2020 Aug 1;205(3):789-800. doi: 10.4049/jimmunol.2000319. Epub 2020 Jun 19. PMID: 32561569.

10: Puelles VG, Lütgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, Chilla S, Heinemann A, Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schröder AS, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Kluge S, Pueschel K, Aepfelbacher M, Huber TB. Multiorgan and Renal Tropism of SARS-CoV-2. N Engl J Med. 2020 Aug 6;383(6):590-592. doi: 10.1056/NEJMc2011400. Epub 2020 May 13. PMID: 32402155; PMCID: PMC7240771.

11: Buhl EM, Djudjaj S, Klinkhammer BM, Ermert K, Puelles VG, Lindenmeyer MT, Cohen CD, He C, Borkham-Kamphorst E, Weiskirchen R, Denecke B, Trairatphisan P, Saez-Rodriguez J, Huber TB, Olson LE, Floege J, Boor P. Dysregulated mesenchymal PDGFR-β drives kidney fibrosis. EMBO Mol Med. 2020 Mar 6;12(3):e11021. doi: 10.15252/emmm.201911021. Epub 2020 Jan 14. PMID: 31943786; PMCID: PMC7059015.

12: Randi EB, Vervaet B, Tsachaki M, Porto E, Vermeylen S, Lindenmeyer MT, Thuy LTT, Cohen CD, Devuyst O, Kistler AD, Szabo C, Kawada N, Hankeln T, Odermatt A, Dewilde S, Wenger RH, Hoogewijs D. The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease. Antioxid Redox Signal. 2020 Jun 1;32(16):1155-1171. doi: 10.1089/ars.2019.7868. Epub 2020 Feb 6. PMID: 31910047.

13: Kliewe F, Kaling S, Lötzsch H, Artelt N, Schindler M, Rogge H, Schröder S, Scharf C, Amann K, Daniel C, Lindenmeyer MT, Cohen CD, Endlich K, Endlich N. Fibronectin is up-regulated in podocytes by mechanical stress. FASEB J. 2019 Dec;33(12):14450-14460. doi: 10.1096/fj.201900978RR. Epub 2019 Nov 1. PMID: 31675484.

14: Lorenz G, Moschovaki-Filippidou F, Würf V, Metzger P, Steiger S, Batz F, Carbajo-Lozoya J, Koziel J, Schnurr M, Cohen CD, Schmaderer C, Anders HJ, Lindenmeyer M, Lech M. IFN Regulatory Factor 4 Controls Post-ischemic Inflammation and Prevents Chronic Kidney Disease. Front Immunol. 2019 Oct 1;10:2162. doi: 10.3389/fimmu.2019.02162. PMID: 31632388; PMCID: PMC6781770.

15: Puelles VG, van der Wolde JW, Wanner N, Scheppach MW, Cullen-McEwen LA, Bork T, Lindenmeyer MT, Gernhold L, Wong MN, Braun F, Cohen CD, Kett MM, Kuppe C, Kramann R, Saritas T, van Roeyen CR, Moeller MJ, Tribolet L, Rebello R, Sun YB, Li J, Müller-Newen G, Hughson MD, Hoy WE, Person F, Wiech T, Ricardo SD, Kerr PG, Denton KM, Furic L, Huber TB, Nikolic-Paterson DJ, Bertram JF. mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans. JCI Insight. 2019 Sep 19;4(18):e99271. doi: 10.1172/jci.insight.99271. PMID: 31534053; PMCID: PMC6795295.