Genetic and epigenetic kidney disease

For early-onset kidney disease, such as steroid-resistant nephrotic syndrome, but also adult-onset kidney disease, such as Fabry’s disease, multiple monogenic or polygenic causes have been identified. Additionally, many risk alleles as well as epigenetically regulated genes are known to influence onset, treatment and prognosis of kidney disease.

Using transgenic mouse models, iPSC-derived or CRISPR KO kidney organoids as well as novel diagnostic panels, we aim to uncover known and novel effectors of disease to advance knowledge and personalize treatment of kidney disease.  

Martinistraße 52
Campus Research N27
20246 Hamburg Germany
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University Medical Center Hamburg - Eppendorf