HCKH - Markus Rinschen - Hamburg Center for Kidney Health

Laboratory for systems medicine and inflammation research

Markus Rinschen
.
- TEAM MEMBERS
- RESEARCH
- CV
- PUBLICATIONS
- FUNDING

Markus Rinschen

Mission Statement

“Understanding the molecular tissue pathophysiology and metabolism to provide new avenues to treat and intervene with progression of chronic kidney disease”

— Markus Rinschen, MD

Team Members

Technician

Stefan Gatzemeier

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PhD student

Arvid Hutzfeldt

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Post Doc, Laboratory Head

Moritz Lassé, PhD

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PhD Student

Lars Nilges

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Research

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Podocyte-specific integrated omic targets. ©Markus Rinschen

The laboratory of kidney omics and metabolism investigates the molecular processes that lead to chronic kidney disease. One out of ten people suffer from chronic kidney disease, an unmet burden to individuals and societies. Common causes are hypertension, diabetes, or genetic or environmental factors. Our key hypothesis is that understanding of molecular tissue pathophysiology and metabolism provides new avenues to treat and intervene with progression of chronic kidney disease. To approach this, we use a wide array of metabolic, mass spectrometric and bioinformatics tools, and integrate and benchmark big data sets with physiological function. Our results have unraveled new approaches and omics-guided targets for kidney disease in mice and men, in particular in the area of glomerular kidney disease.

Markus Rinschen, MD

Systems Medicine and Translational Inflammatory Research

III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE)
Martinistr. 52
20246 Hamburg, Germany

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CV

Current Position

since 2021	Principal Investigator, CRC1192, Project B10
since 2020	Associate Professor, Department of Biomedicine, Aarhus, Denmark
since 2020	Full Professor, III. Department of Medicine, Hamburg, Germany

University Training

2004 - 2011

Study of Medicine, WWU Münster

Academic qualifications

2011 - 2020

MD thesis, Internal Medicine D, University Hospital Muenster, Muenster, Germany and NHLBI, NIH, Bethesda, MD, USA. Supervisor: Eberhard Schlatter, PhDKE

Previous professional career

2018 - 2020	Visiting Investigator, Scripps Research, CA, USA
2011 - 2017	Scientist, II. Department of Medicine, Cologne, Germany

Selected awards and honors

2021 - 20230	MSCA COFUNDII-Scholarship, Aarhus Institute for Advanced Sciences, Aarhus University, Denmark
2020	Physiological Omics New Investigator Award, American Physiological Society (APS)
2020	Guyton Award for Excellence in Integrative Physiology or Medicine, APS
2020	Novo Nordisk Foundation Young Investigator Award
2018	Research Recognition Award for junior faculty, Renal Section, APS
2018	Wissenschaftspreis des Industrieclubs Düsseldorf, Germany. Statewide interdisciplinary award for innovative applied research in the area of “life sciences or medicine”
2018	Du Bois-Reymond Award, German Physiological Society, with Keynote at europhysiology
2018	Carl-Ludwig-Award, German Nephrology
2017	Research Recognition Award for meritorious postdoctoral work, APS
2011	Rainer Greger Award for best MD or PhD thesis, German Society of Nephrology (DGFN)

Selected publications

1.	VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney. Rinschen MM, Harder JL, Carter-Timofte ME, Zanon Rodriguez L, Mirabelli C, Demir F, Kurmasheva N, Ramakrishnan SK, Kunke M, Tan Y, Billing A, Dahlke E, Larionov AA, Bechtel-Walz W, Aukschun U, Grabbe M, Nielsen R, Christensen EI, Kretzler M, Huber TB, Wobus CE, Olagnier D, Siuzdak G, Grahammer F, Theilig F. Sci Signal. 2022 Nov 29;15(762):eabo7940.
2.	Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension. Rinschen MM, Palygin O, El-Meanawy A, Domingo-Almenara X, Palermo A, Dissanayake LV, Golosova D, Schafroth MA, Guijas C, Demir F, Jaegers J, Gliozzi ML, Xue J, Hoehne M, Benzing T, Kok BP, Saez E, Bleich M, Himmerkus N, Weisz OA, Cravatt BF, Krüger M, Benton HP, Siuzdak G, Staruschenko A. Nat Commun.* 2022;13(1):4099.
3.	Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis.. Koehler S, Kuczkowski A, Kuehne L, Jüngst C, Hoehne M, Grahammer F, Eddy S, Kretzler M, Beck BB, Höhfeld J, Schermer B, Benzing T, Brinkkoetter PT, Rinschen MM. J Am Soc Nephrol. 2020;31(3):544-559.
4.	Identification of bioactive metabolites using activity metabolomics. Rinschen MM, Ivanisevic J, Giera M, Siuzdak G. Nat Rev Mol Cell Biol. 2019;20(6):353-367.
5.	Metabolic rewiring of the hypertensive kidney. Rinschen MM, Palygin O, Guijas C, Palermo A, Palacio-Escat N, Domingo-Almenara X, Montenegro-Burke R, Saez-Rodriguez J, Staruschenko A, Siuzdak G. Sci Signal. 2019;12(611):eaax9760.
6.	The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury. Späth MR, Bartram MP, Palacio-Escat N, Hoyer KJR, Debes C, Demir F, Schroeter CB, Mandel AM, Grundmann F, Ciarimboli G, Beyer A, Kizhakkedathu JN, Brodesser S, Göbel H, Becker JU, Benzing T, Schermer B, Höhne M, Burst V, Saez-Rodriguez J, Huesgen PF, Müller RU, Rinschen MM. Kidney Int. 2019;95(2):333-349.
7.	A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes. Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB. Cell Rep. 2018;23(8):2495-2508.
8.	Single-nephron proteomes connect morphology and function in proteinuric kidney disease. Höhne M, Frese CK, Grahammer F, Dafinger C, Ciarimboli G, Butt L, Binz J, Hackl MJ, Rahmatollahi M, Kann M, Schneider S, Altintas MM, Schermer B, Reinheckel T, Göbel H, Reiser J, Huber TB, Kramann R, Seeger-Nukpezah T, Liebau MC, Beck BB, Benzing T, Beyer A, Rinschen MM. Kidney Int. 2018;93(6):1308-1319.
9.	The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia. Kohli P, Höhne M, Jüngst C, Bertsch S, Ebert LK, Schauss AC, Benzing T, Rinschen MM, Schermer B. EMBO Rep. 2017;18(9):1521-1535.
10.	Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations. Laghmani K, Beck BB, Yang SS, Seaayfan E, Wenzel A, Reusch B, Vitzthum H, Priem D, Demaretz S, Bergmann K, Duin LK, Göbel H, Mache C, Thiele H, Bartram MP, Dombret C, Altmüller J, Nürnberg P, Benzing T, Levtchenko E, Seyberth HW, Klaus G, Yigit G, Lin SH, Timmer A, de Koning TJ, Scherjon SA, Schlingmann KP, Bertrand MJ, Rinschen MM, de Backer O, Konrad M, Kömhoff M. Polyhydramnios, N Engl J Med. 2016;374(19):1853-63.
11.	Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Rinschen MM, Yu MJ, Wang G, Boja ES, Hoffert JD, Pisitkun T, Knepper MA. Proc Natl Acad Sci U S A. 2010;107(8):3882-7.