Laboratory for molecular analysis of kidney development and disease

Nicola Wanner

Mission Statement

“Utilizing the power of epigenetic and transcriptional regulation to understand kidney cells in development and disease”

— Nicola Wanner, PhD

Team Members

Post Doc

Dinh To Le, PhD

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Research

©Nicola Wanner

We are using epigenetic and transcriptional profiling, imaging and nanobodies to understand nephrology: From environmental stressors causing disruption in renal development and the impact of epigenetic regulation of nephrogenesis to investigating renal diseases such as glomerulonephritis and the interaction between the immune system and renal cells, we are exploring multiple facets of renal physiology and disease. As members of the CRC 1192, we use nanobody technology to develop novel treatment strategies for kidney diseases.

Nicola Wanner, PhD

III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE)
Martinistr. 52
20246 Hamburg, Germany

CV

Current position
since 2020

Junior group leader/Principal Investigator CRC 1192 Project B5

since 2017

Laboratory head, III. Medical Department, University Medical Center Hamburg Eppendorf, Prof. Dr. T.B. Huber

University training
2004 - 2009

Molecular Medicine at the Albert-Ludwigs University Freiburg im Breisgau, Germany

Academic qualifications
2013 - 2017

PhD at the University of Freiburg – Spemann Graduate School of Biology and Medicine (summa cum laude)

2009 - 2017

Diploma in Molecular Medicine at the University of Freiburg

Previous professional career
2013 - 2017

Postdoctoral Fellow, Department of Nephrology, University Hospital Freiburg, Germany, Prof. Dr. Tobias B. Huber

Selected awards and honors

2024

Award of the UKE Foundation

2014 - 2020

Rainer-Greger Prize for PhD thesis in Nephrology

2009 - 2013

2009 - 2013 PhD Fellowship of the Spemann Graduate School of Biology and Medicine (SGBM)

Selected publications

1.

ATP-Gated P2X7-Ion Channel on Kidney-Resident Natural Killer T Cells and Memory T Cells in Intrarenal Inflammation.
Junge M, Liaukouskaya N, Schwarz N, Pinto-Espinoza C, Schaffrath AZ, Rissiek B, Krebs CF, Rattay G, Mittrücker HW, Tomas NM, Nicke A, Haag F, Huber TB, Meyer-Schwesinger C, Koch-Nolte F, Wanner N. J Am Soc Nephrol. 2024 Dec 9. 

2.

Adeno-associated virus-based gene therapy treats inflammatory kidney disease in mice.
Wu G, Liu S, Hagenstein J, Alawi M, Hengel FE, Schaper M, Akyüz N, Liao Z, Wanner N, Tomas NM, Failla AV, Dierlamm J, Körbelin J, Lu S, Huber TB.  J Clin Invest. 2024 Aug 15;134(17):e174722.

3.

Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens.
Kylies D, Zimmermann M, Haas F, Schwerk M, Kuehl M, Brehler M, Czogalla J, Hernandez LC, Konczalla L, Okabayashi Y, Menzel J, Edenhofer I, Mezher S, Aypek H, Dumoulin B, Wu H, Hofmann S, Kretz O, Wanner N, Tomas NM, Krasemann S, Glatzel M, Kuppe C, Kramann R, Banjanin B, Schneider RK, Urbschat C, Arck P, Gagliani N, van Zandvoort M, Wiech T, Grahammer F, Sáez PJ, Wong MN, Bonn S, Huber TB, Puelles VG.  Nat Nanotechnol. 2023 Apr;18(4):336-342. 

4.

Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy
Braun F, Abed A, Sellung D, Rogg M, Woidy M, Eikrem O, Wanner N, Gambardella J, Laufer SD, Haas F, Wong MN, Dumoulin B, Rischke P, Mühlig A, Sachs W, von Cossel K, Schulz K, Muschol N, Gersting SW, Muntau AC, Kretz O, Hahn O, Rinschen MM, Mauer M, Bork T, Grahammer F, Liang W, Eierhoff T, Römer W, Hansen A, Meyer-Schwesinger C, Iaccarino G, Tøndel C, Marti HP, Najafian B, Puelles VG, Schell C, Huber TB. J Clin Invest. 2023 Jun 1;133(11):e157782. 

5.

Molecular consequences of SARS-CoV-2 liver tropism.
Wanner N, Andrieux G, Badia-i-Mompel P, Edler C, Pfefferle S, Lindenmeyer M, Schmidt-Lauber C, Czogalla J, Wong MN, Okabayashi Y, Braun F, Lütgehetmann M, Meister E, Lu S, Noriega MLM, Günther T, Grundhoff A, Fischer N, Bräuninger H, Lindner D, Westermann D, Haas F, Roedl K, Kluge S, Addo MM, Huber S, Lohse AW, Reiser J, Ondruschka B, Sperhake JP, Saez-Rodriguez J, Boerries M, Hayek SS, Aepfelbacher M, Scaturro P, Puelles VG, Huber TB. Nat Metab 2022 Mar;4(3):310-319.

6.

Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development.
Fuhrmann L, Lindner S, Hauser AT, Höse C, Kretz O, Cohen CD, Lindenmeyer MT, Sippl W, Jung M, Huber TB, Wanner N. Int J Mol Sci. 2021 Apr 16;22(8):4157.

7.

Multiorgan and Renal Tropism of SARS-CoV-2.
Puelles VG, Lütgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, Chilla S, Heinemann A, Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schröder AS, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Kluge S, Pueschel K, Aepfelbacher M, Huber TB. N Engl J Med. 2020 Aug 6;383(6):590-592.

8.

mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans.
Puelles VG, van der Wolde JW, Wanner N, Scheppach MW, Cullen-McEwen LA, Bork T, Lindenmeyer MT, Gernhold L, Wong MN, Braun F, Cohen CD, Kett MM, Kuppe C, Kramann R, Saritas T, van Roeyen CR, Moeller MJ, Tribolet L, Rebello R, Sun YB, Li J, Müller-Newen G, Hughson MD, Hoy WE, Person F, Wiech T, Ricardo SD, Kerr PG, Denton KM, Furic L, Huber TB, Nikolic-Paterson DJ, Bertram JF. JCI Insight. 2019 Sep 19;4(18):e99271.

9.

DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.
Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles VG, Rahman RU, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek ME, Romano T, Moritz KM, Boerries M, Busch H, Bonn S, Little MH, Bechtel-Walz W, Huber TB. J Am Soc Nephrol. 2019 Jan;30(1):63-78.

10.

Unraveling the role of podocyte turnover in glomerular aging and injury.
Wanner N, Hartleben B, Herbach N, Goedel M, Stickel N, Zeiser R, Walz G, Moeller MJ, Grahammer F, Huber TB. J Am Soc Nephrol. 2014 Apr;25(4):707-16.

Funding

Martinistraße 52
Campus Research II N25
20246 Hamburg Germany
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University Medical Center Hamburg - Eppendorf