HCKH - PI Nicola Wanner - Hamburg Center for Kidney Health

Laboratory for molecular analysis of kidney development and disease

Nicola Wanner
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- TEAM MEMBERS
- RESEARCH
- CV
- PUBLICATIONS
- FUNDING

Nicola Wanner

Mission Statement

“Utilizing the power of epigenetic and transcriptional regulation to understand kidney cells in development and disease”

— Nicola Wanner, PhD

Team Members

PhD student

Nastassia Liaukouskaya

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Research

Zoom

©Nicola Wanner

We are using epigenetic and transcriptional profiling, imaging and nanobodies to understand nephrology: From environmental stressors causing disruption in renal development and the impact of epigenetic regulation of nephrogenesis to investigating renal diseases such as glomerulonephritis and the interaction between the immune system and renal cells, we are exploring multiple facets of renal physiology and disease. As members of the CRC 1192, we are using nanobody technology to develop novel treatment strategies for kidney diseases.

Nicola Wanner, PhD

III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE)

Martinistr. 52
20246 Hamburg, Germany

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CV

Current position

since 2020	Junior group leader/Principal Investigator CRC 1192 Project B5
since 2017	Laboratory head, III. Medical Department, University Medical Center Hamburg Eppendorf, Prof. Dr. T.B. Huber

University training

2004 - 2009

Molecular Medicine at the Albert-Ludwigs University Freiburg im Breisgau, Germany

Academic qualifications

2013 - 2017	PhD at the University of Freiburg – Spemann Graduate School of Biology and Medicine (summa cum laude)
2009 - 2017	Diploma in Molecular Medicine at the University of Freiburg

Previous professional career

2013 - 2017

Postdoctoral Fellow, Department of Nephrology, University Hospital Freiburg, Germany, Prof. Dr. Tobias B. Huber

Selected awards and honors

2014 - 2020	Rainer-Greger Prize for PhD thesis in Nephrology
2009 - 2013	2009 - 2013 PhD Fellowship of the Spemann Graduate School of Biology and Medicine (SGBM)

Selected publications

1.	Molecular consequences of SARS-CoV-2 liver tropism. Wanner N, Andrieux G, Badia-i-Mompel P, Edler C, Pfefferle S, Lindenmeyer M, Schmidt-Lauber C, Czogalla J, Wong MN, Okabayashi Y, Braun F, Lütgehetmann M, Meister E, Lu S, Noriega MLM, Günther T, Grundhoff A, Fischer N, Bräuninger H, Lindner D, Westermann D, Haas F, Roedl K, Kluge S, Addo MM, Huber S, Lohse AW, Reiser J, Ondruschka B, Sperhake JP, Saez-Rodriguez J, Boerries M, Hayek SS, Aepfelbacher M, Scaturro P, Puelles VG, Huber TB. Nat Metab 2022 Mar;4(3):310-319.
2.	BET Proteins Regulate Expression of Osr1 in Early Kidney Development. Schreiber J, Liaukouskaya N, Fuhrmann L, Hauser AT, Jung M, Huber TB, Wanner N. Biomedicines. 2021 Dec 10;9(12):1878.
3.	Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development. Fuhrmann L, Lindner S, Hauser AT, Höse C, Kretz O, Cohen CD, Lindenmeyer MT, Sippl W, Jung M, Huber TB, Wanner N. Int J Mol Sci. 2021 Apr 16;22(8):4157.
4.	Multiorgan and Renal Tropism of SARS-CoV-2. Puelles VG, Lütgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, Chilla S, Heinemann A, Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schröder AS, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Kluge S, Pueschel K, Aepfelbacher M, Huber TB. N Engl J Med. 2020 Aug 6;383(6):590-592.
5.	mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans. Puelles VG, van der Wolde JW, Wanner N, Scheppach MW, Cullen-McEwen LA, Bork T, Lindenmeyer MT, Gernhold L, Wong MN, Braun F, Cohen CD, Kett MM, Kuppe C, Kramann R, Saritas T, van Roeyen CR, Moeller MJ, Tribolet L, Rebello R, Sun YB, Li J, Müller-Newen G, Hughson MD, Hoy WE, Person F, Wiech T, Ricardo SD, Kerr PG, Denton KM, Furic L, Huber TB, Nikolic-Paterson DJ, Bertram JF. JCI Insight. 2019 Sep 19;4(18):e99271.
6.	DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation. Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles VG, Rahman RU, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek ME, Romano T, Moritz KM, Boerries M, Busch H, Bonn S, Little MH, Bechtel-Walz W, Huber TB. J Am Soc Nephrol. 2019 Jan;30(1):63-78.
7.	Unraveling the role of podocyte turnover in glomerular aging and injury. Wanner N, Hartleben B, Herbach N, Goedel M, Stickel N, Zeiser R, Walz G, Moeller MJ, Grahammer F, Huber TB. J Am Soc Nephrol. 2014 Apr;25(4):707-16.