Research Group for Interorgan Communication

Nikolai P. Jaschke

Mission Statement

“Dissecting the physiology of neuroendocrine interorgan communication for identification of novel therapeutic concepts”

— Nikolai P. Jaschke MD/PhD

Team Members

Post Doc

Boyong Wei, PhD

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Technician

Maria Mader

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Post Doc

Riccardo Dore, PhD

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Research

Our lab is broadly interested in how brain and body talk to each other in health and disease and which physiological and behavioral adaptations arise from this communication. We are particularly curious about the influence of environmental factors such as the diet, social bonds, infectious pathogens or xenobiotics on brain-body communication, and which therapeutic strategies can be inferred from understanding this biology. 

The scientific approach of our group is primarily hypothesis driven. We seek to ask innovative and simple questions, followed by systematically addressing these using state-of-the art experimental approaches. Our philosophy builds on two major premises: first, understanding physiology is a prerequisite for making sense of pathology and second, studying the body as a holistic system, rather than focusing on individual organs is necessary for identification of innovative therapeutic targets. We believe that this is the case because most modern diseases for which we seek cures for are driven by systemic, rather than tissue-intrinsic factors. Our aspiration is to pursue highly interdisciplinary projects spanning a range of fields including metabolism research, behavioral biology, neurosciences, evolutionary biology, comparative physiology, immunology, oncology and biochemistry. Due to our clinical background, we have access to human specimens, which we use to validate our experimental observations wherever possible. 

Our work is thus situated at the intersection of basic science and medicine, seeking to translate insights from physiology into pharmacological or dietary interventions to sustain and/or restore health. We are a highly collaborative group with a deep appreciation for different perspectives from various fields. Come do science with us!

Nikolai P. Jaschke, MD, PhD

Junior Group Leader

I. & III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE)
Martinistr. 52
20246 Hamburg, Germany

CV

Current Position
since 2025 Principal Investigator, Interorgan Communication Lab, Department of Medicine I & III, University Medical Center Hamburg-Eppendorf
since 2025
Resident physician, Department of Medicine III, Division of Endocrinology, University Medical Center Hamburg-Eppendorf
since 2025 Assistant Professor Adjunct, Department of Medicine, Yale School of Medicine
University Training
2012 - 2018

Medical School, Medical University Innsbruck, Austria

2012 - 2018 Clerkships at National Jewish Health, Denver (CO, USA), Max-Planck Institute for Psychiatry Munich, Centre for Reproductive Medicine and Andrology (CeRa) Munster, among others
Academic qualifications
2022- 2020

Ph.D, Technical University of Dresden, Germany

2018

M.D., Medical University of Innsbruck, Austria

Previous professional career

Clinical postgraduate education:

since 2025

Resident physician, Department of Medicine III, Division of Endocrinology, UKE, Hamburg, Germany

2022 - 2023

Resident Physician, Department of Medicine III, University Hospital Dresden, Germany

2018

Resident Physician, Department of Medicine I, University Hospital Wuerzburg, Germany

Scientific postgraduate education:

since 2025

iPRIME Clinician Scientist fellow Else-Kröner Fresenius Foundation

2023 - 2025

Postdoctoral Fellow, Wang Lab, Yale School of Medicine, CT, USA

2022

Research Fellow, Swirski Lab, Icahn School of Medicine, NYC, USA

2018 – 2022 Ph.D student, Bone Lab, Technical University of Dresden & Gastro Lab, Medical University of Innsbruck, Austria
Selected awards and honors
202520

Roland Ernst Foundation Research Award

2025

Schoeller Junkmann Award, German Society of Endocrinology

2025

 Keystone Symposia Future of Science Fund Scholarship

2024  Travel Scholarship, Janelia Conferences, Howard Hughes Medical Institute
2021  Van Recklinghausen Award, German Society of Endocrinology
2016  Ferring Young Investigator Award, Austrian Society of Reproductive Medicine
2014  Scholarship for excellent study performance, Medical University of Innsbruck

Selected publications

1.
Jaschke NP*, Luchsinger JR, Chen Z, Wulfmeyer VC, de la Rosa X, Hahn O, Zhang C, Bachtel ND, Cullen JL, Rachner TD, Medzhitov R, Rinschen MM, Wu C, Wang A. Cell. 2025 Dec 24;188(26):7481-7494.e16. 
2.
Jaschke NP*, Breining D, Hofmann M, Pählig S, Baschant U, Oertel R, Traikov S, Grinenko T, Saettini F, Biondi A, Stylianou M, Bringmann H, Zhang C, Yoshida TM, Weidner H, Poller WC, Swirski FK, Göbel A, Hofbauer LC, Rauner M, Scheiermann C, Wang A, Rachner TD. Immunity. 2024 Feb 13;57(2):364-378.e9.
3.
Jaschke NP*, Pählig S, Sinha A, Adolph TE, Colunga ML, Hofmann M, Wang A, Thiele S, Schwärzler J, Kleymann A, Gentzel M, Tilg H, Wielockx B, Hofbauer LC, Rauner M, Göbel A, Rachner TD. Commun Biol. 2022 Dec 20;5(1):1391. 
4.
Jaschke NP*, Funk AM, Jonas S, Riffel RM, Sinha A, Wang A, Pählig S, Hofmann M, Altmann H, Von Bonin S, Koch T, Spieth P, Tausche K, Akgün K, Rauner M, Kronstein-Wiedemann R, Odendahl M, Tonn T, Göbel A, Hofbauer LC, Rachner TD. J Clin Endocrinol Metab. 2022 Nov 25;107(12):3370-3377.
5.

Integrated control of leukocyte compartments as a feature of adaptive physiology.
Jaschke NP*, Wang A. Immunity. 2025 Feb 11;58(2):279-294. 

6.

Control loop designs in health and disease.
Jaschke NP*. Nat Rev Endocrinol. 2022 Nov;18(11):653-654. 

*corresponding author

Funding

News

March 22–24, 2026 | Münster
March 28-31, 2026 | Yokohama, Japan
February 2026 | News

Martinistraße 52
Campus Research II N25
20246 Hamburg Germany
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University Medical Center Hamburg - Eppendorf