Mission Statement

“Facilitate translational renal research and provide a valuable source to accelerate the development of better patient diagnostics and therapies – only together we can make a difference”

— Maja Lindenmeyer, PhD

Team Members

Study nurse

Marigona Agushi

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Technician

Silvia Chilla

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Technician

Ilka Edenhofer

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CLINICIAN SCIENTIST

Sydney Gies, MD

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Study nurse

Inga Komisarenko

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Study nurse

Samaneh Liagos

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Clinician Scientist

Elisabeth Meister, MD

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Post Doc

Nikolay Zolotarev, PhD

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Research

©Maja Lindenmeyer, created with BioRender

Our group represents the core facility of the “European Renal cDNA Bank-Kroener Fresenius Biopsy Bank” (ERCB-KFB), a multicenter study for gene expression analysis in different human renal diseases, and the “Hamburg and European Renal Omics Bank” (HERO), a collaborative project for conducting translational research in human renal diseases. Using state-of-the art Omics and non-Omics technologies we aim to

  1. support the renal scientific community by translational research
  2. expand our knowledge of disease pathomechanisms
  3. define molecular disease subgroups
  4. identify biomarkers
  5. find new ways treating human renal diseases.

Maja Lindenmeyer, PhD

LABORATORY HEAD/HEAD OF BIOBANK

III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE)
Martinistr. 52
20246 Hamburg, Germany

CV

Current Position
since 2022 Principal Investigator / Co-Coordinator BMBF STOP-FSGS
since 2022

Principal Investigator BMBF UPTAKE

since 2021

Project Leader/ Study Coordinator of the Hamburg and European Renal Omics Biobank (HERO)

since 2018

Laboratory head, III. Department of Medicine, UKE, Prof. Dr. T. B. Huber

since 2018 Coordinator of the ERCB
University Training
1994 – 2000

Chemistry, Technical University Karlsruhe, University of Freiburg

Academic qualifications
2014 - 2020

Habilitation in Molecular Nephrology, University of Zurich (Switzerland)

2004

PhD, Department of Pharmaceutical Biology and Biotechnology, University of Freiburg

2000

Diploma in Chemistry, University of Freiburg

Previous professional career

2015 – 2018

Junior Group leader, Nephrology Center, IV. Department of Medicine, University Hospital of Munich (LMU)

2012 – 2018

Deputy-Coordinator of the European Renal cDNA Bank-Kroener Fresenius
Biobank (ERCB)

2010 – 2014

Laboratory Head of the Nephrology Lab Zurich, University of Zurich (Switzerland)

2008 – 2010

Postdoctoral Fellow, Institute of Physiology and Division of Nephrology, University of Zurich (Switzerland), Prof. Dr. C. Cohen

2006 – 2007

Postdoctoral Fellow, Nephrology Center, IV. Deparment of Medicine, University Hospital of Munich (LMU), Prof Dr. C. Cohen

2004 – 2005

Postdoctoral Fellow, School of Biological Sciences, Queen Mary College, London (UK), Prof. Dr. M. Warren

Selected awards and honors
2010 - 2020

Habilitation Scholarship of the Holcim Foundation

2004 – 2005

Post-Doc fellowship of the German Academic Exchange Service (DAAD)

2001 – 2003

PhD fellowship of the “Landesgraduiertenförderung Baden-Württemberg”

Selected publications

1.

Molecular consequences of SARS-CoV-2 liver tropism.
Wanner N*, Andrieux G*, Badia-i-Mompel P, Edler C, Pfefferle S, Lindenmeyer M, Schmidt-Lauber C, Czogalla J, Wong MN, Okabayashi Y, Braun F, Lütgehetmann M, Meister E, Lu S, Noriega MLM, Günther T, Grundhoff A, Fischer N, Bräuninger H, Lindner D, Westermann D, Haas F, Roedl K, Kluge S, Addo MM, Huber S, Lohse AW, Reiser J, Ondruschka B, Sperhake JP, Saez-Rodriguez J, Boerries M, Hayek SS, Aepfelbacher M, Scaturro P*, Puelles VG*, Huber TB*. Nat Metab 2022 Mar;4(3):310-319

2.

Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting.
Solagna F, Tezze C, Lindenmeyer MT, Lu S, Wu G, Liu S, Zhao Y, Mitchell R, Meyer C, Omairi S, KilicT, Paolini A, Ritvos O, Pasternack A, Matsakas A, Kylies D, Wiesch JS zur, Turner J-E, Wanner N, Nair V, Eichinger F, Menon R, Martin I V., Klinkhammer BM, Hoxha E, Cohen CD, Tharaux P-L, Boor P, Ostendorf T, Kretzler M, Sandri M, Kretz O, Puelles VG*, Patel K*, Huber TB*, J Clin Invest. 2021 Jun 1;131(11).

3.

Endothelial-Specific Deletion of CD146 Protects Against Experimental Glomerulonephritis in Mice.
Abed A*, Leroyer AS*, Kavvadas P*, Authier F, Bachelier R, Foucault-Bertaud A, Bardin N, Cohen CD, Lindenmeyer MT, Genest M, Joshkon A, Jourde-Chiche N, Burtey S, Blot-Chabaud M, Dignat-George F*, Chadjichristos CE*. Hypertension. 2021 Apr;77(4):1260-1272

4.

SARS-CoV-2 renal tropism associates with acute kidney injury.
Braun F, Lütgehetmann M, Pfefferle S, Wong MN, Carsten A, Lindenmeyer MT, Nörz D, Heinrich F, Meißner K, Wichmann D, Kluge S, Gross O, Pueschel K, Schröder AS, Edler C, Aepfelbacher M, Puelles VG, Huber TB. Lancet. 2020 Aug;396(10251):597–8.

5.

ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage.
Sachs M, Wetzel S, Reichelt J, Sachs W, Schebsdat L, Zielinski S, Seipold L, Heintz L, Müller SA, Kretz O, Lindenmeyer M, Wiech T, Huber TB, Lüllmann-Rauch R, Lichtenthaler SF, Saftig P, Meyer-Schwesinger C. J Am Soc Nephrol. 2021 Jun 1;32(6):1389-1408

6.

Dysregulated mesenchymal PDGFR-β drives kidney fibrosis
Buhl EM, Djudjaj S, Klinkhammer BM, Ermert K, Puelles VG, Lindenmeyer MT, Cohen CD, He C, Borkham-Kamphorst E, Weiskirchen R, Denecke B, Trairatphisan P, Saez-Rodriguez J, Huber TB, Olson LE, Floege J, Boor P. EMBO Mol Med. 2020 Mar 6;12(3):e11021

7.

Multiorgan and Renal Tropism of SARS-CoV-2.
Puelles VG*, Lütgehetmann M*, Lindenmeyer MT*, Sperhake JP*, Wong MN, Allweiss L, Chilla S, Heinemann A, Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schröder AS, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Kluge S, Pueschel K, Aepfelbacher M, Huber TB. N Engl J Med. 2020 Aug 6;383(6):5902.

8.

Tubular NOX4 expression decreases in chronic kidney disease but does not modify fibrosis evolution.
Rajaram RD, Dissard R, Faivre A, Ino F, Delitsikou V, Jaquet V, Cagarelli T, Lindenmeyer M, Jansen-Duerr P, Cohen C, Moll S, de Seigneux S. Redox Biol. 2019 Sep;26:101234

9.

Metabolic pathways and immunometabolism in rare kidney diseases.
Grayson PC, Eddy S, Taroni JN, Lightfoot YL, Mariani L, Parikh H, Lindenmeyer MT, Ju W, Greene CS, Godfrey B, Cohen CD, Krischer J, Kretzler M, Merkel PA; Vasculitis Clinical Research Consortium, the European Renal cDNA Bank cohort, and the Nephrotic Syndrome Study Network. Ann Rheum Dis. 2018 Aug;77(8):1226-1233.

10.

Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts.
Shved N, Warsow G, Eichinger F, Hoogewijs D, Brandt S, Wild P, Kretzler M, Cohen CD, Lindenmeyer MT. Sci Rep. 2017 Aug 17;7(1):8576.

*contributed equally

Funding

Martinistraße 52
Campus Research N27
20246 Hamburg Germany
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University Medical Center Hamburg - Eppendorf