HCKH - PI Tobias Huber - Hamburg Center for Kidney Health

Laboratory for molecular and translational nephrology

Tobias B. Huber
.
- TEAM MEMBERS
- RESEARCH
- CV
- PUBLICATIONS
- FUNDING

Tobias B. Huber

Mission Statement

“Enabling and performing excellence in clinical and molecular nephrology”

— Tobias B. Huber, MD

Team Members

Study nurse

Marigona Agushi

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PhD student

Karl King Alornyo

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Junior Group Leader

Fabian Braun, MD

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Technician

Silvia Chilla

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Clinician Scientist

Jan Czogalla, MD

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Technician

Ilka Edenhofer

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Junior Group Leader

Tilo Freiwald, MD

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CLINICIAN SCIENTIST

Sydney Gies, MD

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Junior Group Leader

Sonja Hänzelmann, PhD

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PhD student

Paris Hazelton-Cavill

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Clinician Scientist

Felicitas Hengel, MD

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Junior Group Leader

Sybille Köhler, PhD

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Study nurse

Inga Komisarenko

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Head of Electron Microscopy Facility

Oliver Kretz, MD

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Post Doc

Sandra Laufer, PhD

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Post Doc

Dinh To Le, PhD

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Study nurse

Samaneh Liagos

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MD student

Zhouning Liao

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PhD student

Nastassia Liaukouskaya

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LABORATORY HEAD/HEAD OF BIOBANK

Maja Lindenmeyer, PhD

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Post Doc

Shuya Liu, PhD

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Post Doc

Shun Lu, PhD

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Clinician Scientist

Elisabeth Meister, MD

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Post Doc

Ming Huang, PhD

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Post Doc

Anne Mühlig, MD/PhD

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Research Coordination

Christiane Neuber, PhD

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Technician

Valerie Oberüber

Technician

Anja Obser

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MD student

Alexander Pausch

Technician

Melanie Schaper

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Clinician Scientist

Christian Schmidt-Lauber, MD

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Research Coordination

Kristina Schulz, PhD

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LABORATORY HEAD/JUNIOR GROUP LEADER

Nicola Wanner, PhD

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PhD student

Guochao Wu

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Laboratory Head/Group Leader

Gunther Zahner, PhD

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Technician

Nina Ziegert

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Assistant Professor

Marina Zimmermann, PhD

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Post Doc

Nikolay Zolotarev, PhD

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Research

Created with BioRender

We aim at a better understanding of podocytopathies, the identification of complex principles of kidney diseases, immune -tissue interactions and interorgan signaling. For this purpose, our lab is advancing the following research areas:

Modern tissue banks and patient registries by means of complex data analysis and attention to data security
Multidimensional techniques for tissue analysis and single-cell biology
Application and development of experimental models for the precise analysis of disease mechanisms
New strategies of gene- and cell targeting in the kidney
Development of translational platforms for the transfer of molecular findings into novel therapies

With this, our aim is to identify new approaches for the prevention, halt and cure of kidney diseases.

Tobias B. Huber, MD

Chair of the Center of Internal Medicine
Director of the III. Department of Medicine

III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE)
Martinistr. 52
20246 Hamburg, Germany

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CV

Current Position

Chair of the Center of Internal Medicine
Director of the III. Department of Medicine

University Training

1992 - 1999

School of Medicine (10/1992-05/1999), Universities of Freiburg, Vienna (Austria) and South Florida (Tampa, USA)

Academic qualifications

2020 - 2020	Chair of the Center of Internal Medicine, UKE
2017	Chair of the III. Department of Medicine, UKE
2015	Chief of the Division of Chronic Kidney Disease, University Medical Center Freiburg (UKF), Germany
2013	W3 Heisenberg Professor, UKF
2008	German Board Certification for Internal Medicine (2008) and Nephrology (2011)
2007	Habilitation, UKF
2005	USMLE US-American Full Medical Licence
1999	M.D. in Physiology (summa cum laude), Department of Physiology, UKF

Previous professional career

Clinical postgraduate education:

2015 - 2017	Deputy Chair, Department of Medicine IV, UKF
2011 - 2015	Senior Attending (Geschäftsführender Oberarzt), UKF
2008 - 2011	Attending Physician, Department of Medicine IV, UKF
2001 - 2003	Fellow in Medicine, Department of Medicine IV, UKF
1999 - 2001	Residency, Department of Medicine IV, UKF

Scientific postgraduate education:

2013 - 2017	W3 Heisenberg Professorship, UKF
2006 - 2011	Emmy Noether Programme – Phase II / Group leader, UKF
2003 - 2006	Emmy Noether Programme – Phase I / Postdoctoral Fellow, Immunology & Pathology, Washington University St. Louis, USA (Laboratory of Prof. Dr. A. Shaw)

Selected awards and honors

2021 - 2020	Elected Member of the National Academy of Sciences – Leopoldina-
2021	Elected Member of the American Association of Physicians
2021	Chair Else Kröner-Fresenius Clinician-Scientist Kolleg “iPRIME-CS”, UKE
2021	Co-Chair BMBF-Advanced Clinician Scientist Program “iSTAR”, UKE
2020	Speaker (together with U. Panzer) of the CRC 1192
2020	DFG-Senate Commission on Key Questions in Clinical Research
2018	Chair Else Kröner-Fresenius MD-Thesis Kolleg “iPRIME”, UKE
2016	Co-Chair Else Kröner-Fresenius Kolleg “NAKSYS”, UKF
2014	Recipient of the European Research Council Grant
2014	Elected Member of the American Society of Clinical Investigation
2012	Young Investigator Award of the American Society of Nephrology (Considered the worldwide highest award for renal research < 45 years)
2010	Franz-Volhard Award of the German Renal Society
2009	Hans U. Zollinger Research Award of German Renal Society
2008	Associated Member of the BIOSS Excellence Cluster, Freiburg
2006	Principal Investigator of the SGBM Graduate School, Freiburg
2004	Carl Ludwig Award of the German Renal Society

Selected publications

1.	Molecular consequences of SARS-CoV-2 liver tropism. Wanner N, Andrieux G, Badia-i-Mompel P, Edler C, Pfefferle S, Lindenmeyer M, Schmidt-Lauber C, Czogalla J, Wong MN, Okabayashi Y, Braun F, Lütgehetmann M, Meister E, Lu S, Noriega MLM, Günther T, Grundhoff A, Fischer N, Bräuninger H, Lindner D, Westermann D, Haas F, Roedl K, Kluge S, Addo MM, Huber S, Lohse AW, Reiser J, Ondruschka B, Sperhake JP, Saez-Rodriguez J, Boerries M, Hayek SS, Aepfelbacher M, Scaturro P, Puelles VG, Huber TB. Nat Metab 2022 Mar;4(3):310-319.
2.	Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs. Solagna F, Tezze C, Lindenmeyer MT, Lu S, Wu G, Liu S, Zhao Y, Mitchell R, Meyer C, Omairi S, Kilic T, Paolini A, Ritvos O, Pasternack A, Matsakas A, Kylies D, Wiesch JS zur, Turner J-E, Wanner N, Nair V, Eichinger F, Menon R, Martin I V., Klinkhammer BM, Hoxha E, Cohen CD, Tharaux P-L, Boor P, Ostendorf T, Kretzler M, Sandri M, Kretz O, Puelles VG, Patel K, Huber TB. J Clin Invest. 2021 Jun 1;131(11).
3.	Podocytes maintain high basal levels of autophagy independent of mtor signaling. Bork T, Liang W, Yamahara K, Lee P, Tian Z, Liu S, Schell C, Thedieck K, Hartleben B, Patel K, Tharaux P-L, Lenoir O, Huber TB. Autophagy. 2020 Nov 1;16(11):1932–48.
4.	Decoding myofibroblast origins in human kidney fibrosis. Kuppe C, Ibrahim MM, Kranz J, Zhang X, Ziegler S, Perales-Patón J, Jansen J, Reimer KC, Smith JR, Dobie R, Wilson-Kanamori JR, Halder M, Xu Y, Kabgani N, Kaesler N, Klaus M, Gernhold L, Puelles VG, Huber TB, Boor P, Menzel S, Hoogenboezem RM, Bindels EMJ, Steffens J, Floege J, Schneider RK, Saez-Rodriguez J, Henderson NC, Kramann R. Nature. 2021 Jan;589(7841):281-286.
5.	SARS-CoV-2 renal tropism associates with acute kidney injury. Braun F, Lütgehetmann M, Pfefferle S, Wong MN, Carsten A, Lindenmeyer MT, Nörz D, Heinrich F, Meißner K, Wichmann D, Kluge S, Gross O, Pueschel K, Schröder AS, Edler C, Aepfelbacher M, Puelles VG, Huber TB. Lancet. 2020 Aug;396(10251):597–8.
6.	Multiorgan and Renal Tropism of SARS-CoV-2. Puelles VG, Lütgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, Chilla S, Heinemann A, Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schröder AS, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Kluge S, Pueschel K, Aepfelbacher M, Huber TB. N Engl J Med. 2020 Aug 6;383(6):590–2.
7.	Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. Brinkkoetter PT, Bork T, Salou S, Liang W, Mizi A, Özel C, Koehler S, Hagmann HH, Ising C, Kuczkowski A, Schnyder S, Abed A, Schermer B, Benzing T, Kretz O, Puelles VG, Lagies S, Schlimpert M, Kammerer B, Handschin C, Schell C, Huber TB. Cell Rep. 2019;27(5):1551-1566.e5.
8.	ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier. Schell C, Sabass B, Helmstaedter M, Geist F, Abed A, Yasuda-Yamahara M, Sigle A, Maier JI, Grahammer F, Siegerist F, Artelt N, Endlich N, Kerjaschki D, Arnold H-H, Dengjel J, Rogg M, Huber TB. Dev Cell. 2018;47(6):741-757.e8.
9.	The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier. Schell C, Rogg M, Suhm M, Helmstädter M, Sellung D, Yasuda-Yamahara M, Kretz O, Küttner V, Suleiman H, Kollipara L, Zahedi RP, Sickmann A, Eimer S, Shaw AS, Kramer-Zucker A, Hirano-Kobayashi M, Abe T, Aizawa S, Grahammer F, Hartleben B, Dengjel J, Huber TB. Proc Natl Acad Sci U S A. 2017;114(23):E4621–30.
10.	mTORC2 critically regulates renal potassium handling. Grahammer F, Nesterov V, Ahmed A, Steinhardt F, Sandner L, Arnold F, Cordts T, Negrea S, Bertog M, Ruegg MA, Hall MN, Walz G, Korbmacher C, Artunc F, Huber TB. J Clin Invest. 2016 May 2;126(5):1773-82.