Laboratory for molecular and translational nephrology

Tobias B. Huber

Mission Statement

“Enabling and performing excellence in clinical and molecular nephrology”

— Tobias B. Huber, MD

Team Members

Study nurse

Marigona Agushi

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PhD student

Karl King Alornyo

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Post-Doc

Lilas Batool, PhD

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PhD Student

Michelle Bouchard

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Junior Group Leader

Fabian Braun, MD

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MD student

Berk Cantutan

Technician

Silvia Chilla

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Clinician Scientist

Jan Czogalla, MD

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Technician

Ilka Edenhofer

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Junior Group Leader

Tilo Freiwald, MD

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CLINICIAN SCIENTIST

Sydney Gies, MD

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MD student

Maja Gunkel

 

 

Post Doc

Yubing Guo, PhD

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Junior Group Leader

Sonja Hänzelmann, PhD

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Clinician Scientist

Felicitas Hengel, MD

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MD student

Julius Jäger

 

 

Junior Group Leader

Sybille Köhler, PhD

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Study nurse

Inga Komisarenko

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Head of Electron Microscopy Facility

Oliver Kretz, MD

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Post Doc

Sandra Laufer, PhD

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Post Doc

Dinh To Le, PhD

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Study nurse

Samaneh Liagos

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MD student

Zhouning Liao

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PhD student

Nastassia Liaukouskaya

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LABORATORY HEAD/HEAD OF BIOBANK

Maja Lindenmeyer, PhD

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Post Doc

Shuya Liu, PhD

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Post Doc

Shun Lu, PhD

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Clinician Scientist

Maya Machalitza, MD

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Clinician Scientist

Elisabeth Meister, MD

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Post Doc

Ming Huang, PhD

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Post Doc

Anne Mühlig, MD/PhD

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Research Coordination

Christiane Neuber, PhD

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Assistant

Y-lan Nguyen-Khanh

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Technician

Valerie Oberüber

Technician

Anja Obser

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MD student

Alexander Pausch

MD student

Götz Rövenstrunk

 

 

Technician

Melanie Schaper

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Clinician Scientist

Christian Schmidt-Lauber, MD

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Head of Research Management

Kristina Schulz, PhD

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LABORATORY HEAD/JUNIOR GROUP LEADER

Nicola Wanner, PhD

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Clinician Scientist

Birte Wöhner, MD

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Post Doc

Guochao Wu

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Laboratory Head/Group Leader

Gunther Zahner, PhD

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Technician

Nina Ziegert

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Assistant Professor

Marina Zimmermann, PhD

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Post Doc

Nikolay Zolotarev, PhD

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Research

Created with BioRender

We aim at a better understanding of podocytopathies, the identification of complex principles of kidney diseases, immune -tissue interactions and interorgan signaling. For this purpose, our lab is advancing the following research areas:

  • Modern tissue banks and patient registries by means of complex data analysis and attention to data security
  • Multidimensional techniques for tissue analysis and single-cell biology
  • Application and development of experimental models for the precise analysis of disease mechanisms
  • New strategies of gene- and cell targeting in the kidney
  • Development of translational platforms for the transfer of molecular findings into novel therapies

With this, our aim is to identify new approaches for the prevention, halt and cure of kidney diseases.

Tobias B. Huber, MD

Chair of the Center of Internal Medicine
Director of the III. Department of Medicine

III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE)
Martinistr. 52
20246 Hamburg, Germany

CV

Current Position

Chair of the Center of Internal Medicine
Director of the III. Department of Medicine

University Training
1992 - 1999

School of Medicine (10/1992-05/1999), Universities of Freiburg, Vienna (Austria) and South Florida (Tampa, USA)

Academic qualifications
2020 - 2020

Chair of the Center of Internal Medicine, UKE

2017

Director of the III. Department of Medicine, UKE

2015

Chief of the Division of Chronic Kidney Disease, University Medical Center Freiburg (UKF), Germany

2013

W3 Heisenberg Professor, UKF

2008

German Board Certification for Internal Medicine (2008) and Nephrology (2011)

2007

Habilitation, UKF

2005

USMLE US-American Full Medical Licence

1999

MD in Physiology (summa cum laude), Department of Physiology, UKF

Previous professional career

Clinical postgraduate education:

2015 - 2017

Deputy Chair, Department of Medicine IV, UKF

2011 - 2015

Senior Attending (Geschäftsführender Oberarzt), UKF

2008 - 2011

Attending Physician, Department of Medicine IV, UKF

2001 - 2003

Fellow in Medicine, Department of Medicine IV, UKF

1999 - 2001

Residency, Department of Medicine IV, UKF

Scientific postgraduate education:

2013 - 2017

W3 Heisenberg Professorship, UKF

2006 - 2011

Emmy Noether Programme – Phase II / Group leader, UKF

2003 - 2006

Emmy Noether Programme – Phase I / Postdoctoral Fellow, Immunology & Pathology, Washington University St. Louis, USA (Laboratory of Prof. Dr. A. Shaw)

Selected awards and honors
2021 - 2020

Elected Member of the National Academy of Sciences – Leopoldina-

2021

Elected Member of the American Association of Physicians

2021

Chair Else Kröner-Fresenius Clinician-Scientist Kolleg “iPRIME-CS”, UKE

2021

Co-Chair BMBF-Advanced Clinician Scientist Program “iSTAR”, UKE

2020

Speaker (together with U. Panzer) of the CRC 1192

2020

DFG-Senate Commission on Key Questions in Clinical Research

2018

Chair Else Kröner-Fresenius MD-Thesis Kolleg “iPRIME”, UKE

2016

Co-Chair Else Kröner-Fresenius Kolleg “NAKSYS”, UKF

2014

Recipient of the European Research Council Grant

2014

Elected Member of the American Society of Clinical Investigation

2012

Young Investigator Award of the American Society of Nephrology (considered the worldwide highest award for renal research < 45 years)

2010

Franz-Volhard Award of the German Renal Society

2009

Hans U. Zollinger Research Award of German Renal Society

2008

Associated Member of the BIOSS Excellence Cluster, Freiburg

2006

Principal Investigator of the SGBM Graduate School, Freiburg

2004

Carl Ludwig Award of the German Renal Society

Selected publications

1.
Hengel FE, Dehde S, Lassé M, Zahner G, Seifert L, Schnarre A, Kretz O, Demir F, Pinnschmidt HO, Grahammer F, Lucas R, Mehner LM, Zimmermann T, Billing AM, Oh J, Mitrotti A, Pontrelli P, Debiec H, Dossier C, Colucci M, Emma F, Smoyer WE, Weins A, Schaefer F, Alachkar N, Diemert A, Hogan J, Hoxha E, Wiech T, Rinschen MM, Ronco P, Vivarelli M, Gesualdo L, Tomas NM, Huber TB; International Society of Glomerular Disease. N Engl J Med. 2024 May 25. doi: 10.1056/NEJMoa2314471. 
2.
Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy.
Braun F, Abed A, Sellung D, Rogg M, Woidy M, Eikrem O, Wanner N, Gambardella J, Laufer SD, Haas F, Wong MN, Dumoulin B, Rischke P, Mühlig A, Sachs W, von Cossel K, Schulz K, Muschol N, Gersting SW, Muntau AC, Kretz O, Hahn O, Rinschen MM, Mauer M, Bork T, Grahammer F, Liang W, Eierhoff T, Römer W, Hansen A, Meyer-Schwesinger C, Iaccarino G, Tøndel C, Marti HP, Najafian B, Puelles VG, Schell C, Huber TB.  J Clin Invest. 2023 Jun 1;133(11):e157782. doi: 10.1172/JCI157782. 
3.
Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens.
Kylies D, Zimmermann M, Haas F, Schwerk M, Kuehl M, Brehler M, Czogalla J, Hernandez LC, Konczalla L, Okabayashi Y, Menzel J, Edenhofer I, Mezher S, Aypek H, Dumoulin B, Wu H, Hofmann S, Kretz O, Wanner N, Tomas NM, Krasemann S, Glatzel M, Kuppe C, Kramann R, Banjanin B, Schneider RK, Urbschat C, Arck P, Gagliani N, van Zandvoort M, Wiech T, Grahammer F, Sáez PJ, Wong MN, Bonn S, Huber TB, Puelles VG. Nat Nanotechnol. 2023 Apr;18(4):336-342. doi: 10.1038/s41565-023-01328-z. 
4.
Loss of the collagen IV modifier prolyl 3-hydroxylase 2 causes thin basement membrane nephropathy
Aypek H, Krisp C, Lu S, Liu S, Kylies D, Kretz O, Wu G, Moritz M, Amann K, Benz K, Tong P, Hu ZM, Alsulaiman SM, Khan AO, Grohmann M, Wagner T, Müller-Deile J, Schlüter H, Puelles VG, Bergmann C, Huber TB, Grahammer F.  J Clin Invest. 2022 May 2;132(9):e147253. doi: 10.1172/JCI147253. 
5.

Molecular consequences of SARS-CoV-2 liver tropism.
Wanner N, Andrieux G, Badia-i-Mompel P, Edler C, Pfefferle S, Lindenmeyer M, Schmidt-Lauber C, Czogalla J, Wong MN, Okabayashi Y, Braun F, Lütgehetmann M, Meister E, Lu S, Noriega MLM, Günther T, Grundhoff A, Fischer N, Bräuninger H, Lindner D, Westermann D, Haas F, Roedl K, Kluge S, Addo MM, Huber S, Lohse AW, Reiser J, Ondruschka B, Sperhake JP, Saez-Rodriguez J, Boerries M, Hayek SS, Aepfelbacher M, Scaturro P, Puelles VG, Huber TB. Nat Metab 2022 Mar;4(3):310-319. doi: 10.1038/s42255-022-00552-6.

6.

Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs.
Solagna F, Tezze C, Lindenmeyer MT, Lu S, Wu G, Liu S, Zhao Y, Mitchell R, Meyer C, Omairi S, Kilic T, Paolini A, Ritvos O, Pasternack A, Matsakas A, Kylies D, Wiesch JS zur, Turner J-E, Wanner N, Nair V, Eichinger F, Menon R, Martin I V., Klinkhammer BM, Hoxha E, Cohen CD, Tharaux P-L, Boor P, Ostendorf T, Kretzler M, Sandri M, Kretz O, Puelles VG, Patel K, Huber TB. J Clin Invest. 2021 Jun 1;131(11). doi: 10.1172/JCI135821. 

7.

Decoding myofibroblast origins in human kidney fibrosis.
Kuppe C, Ibrahim MM, Kranz J, Zhang X, Ziegler S, Perales-Patón J, Jansen J, Reimer KC, Smith JR, Dobie R, Wilson-Kanamori JR, Halder M, Xu Y, Kabgani N, Kaesler N, Klaus M, Gernhold L, Puelles VG, Huber TB, Boor P, Menzel S, Hoogenboezem RM, Bindels EMJ, Steffens J, Floege J, Schneider RK, Saez-Rodriguez J, Henderson NC, Kramann R. Nature. 2021 Jan;589(7841):281-286. doi: 10.1038/s41586-020-2941-1.

8.

Podocytes maintain high basal levels of autophagy independent of mtor signaling.
Bork T, Liang W, Yamahara K, Lee P, Tian Z, Liu S, Schell C, Thedieck K, Hartleben B, Patel K, Tharaux P-L, Lenoir O, Huber TB. Autophagy. 2020 Nov 1;16(11):1932–48. doi: 10.1080/15548627.2019.1705007. 

9.

SARS-CoV-2 renal tropism associates with acute kidney injury.
Braun F, Lütgehetmann M, Pfefferle S, Wong MN, Carsten A, Lindenmeyer MT, Nörz D, Heinrich F, Meißner K, Wichmann D, Kluge S, Gross O, Pueschel K, Schröder AS, Edler C, Aepfelbacher M, Puelles VG, Huber TB. Lancet. 2020 Aug;396(10251):597–8. doi: 10.1016/S0140-6736(20)31759-1. 

10.

Multiorgan and Renal Tropism of SARS-CoV-2.
Puelles VG*, Lütgehetmann M*, Lindenmeyer MT*, Sperhake JP*, Wong MN, Allweiss L, Chilla S, Heinemann A, Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schröder AS, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Kluge S, Pueschel K, Aepfelbacher M, Huber TB. N Engl J Med. 2020 Aug 6;383(6):590–2. doi: 10.1056/NEJMc2011400. 

Funding

News

June 13-16, 2024 | Coex, Seoul, Korea
June 2-4, 2024 | Hamburg, Germany
June 4, 2024 | Lecture, Prof. Dr. Eva Tolosa

Prof. Dr. Eva Tolosa, Institute of Immunology, „T cell Development“ ...

Martinistraße 52
Campus Research N27
20246 Hamburg Germany
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University Medical Center Hamburg - Eppendorf