Mission Statement

“Targeting pro-inflammatory T cell responses in renal autoimmunity”

— Christian Krebs, MD

Team Members

Technician

Alina Borchers

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MD student

Malte Hellmig

Post Doc

Saskia Jauch-Speer, PhD

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Technician

Lilaf Mamo

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MD student

Tobias Neben

PhD student

Varshi Sivayoganathan

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Post Doc

Zeba Sulatana, PhD

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Research

©Christian Krebs

T cells play a critical role in the pathogenesis in autoimmune diseases, by their ability to differentiate into pathogenic effector Th1 and Th17 cells or protective regulatory T cells (Treg). Using multiomics approaches, we characterize human T cells from the kidneys of patients with glomerulonephritis and functionally validate new concepts in preclinical models. 

Our long-term goal is to improve treatment of patients with glomerulonephritis. We will identify mechanisms for a shift of pro-inflammatory Th17 cells towards an anti-inflammatory phenotype and to generate targeted therapies for the depletion of pathogenic T cells in the kidney.

Christian Krebs, MD

Systemsnephrology and Cellular Immunity

III. Department of Medicine, Translational Immunology, University Medical Center Hamburg-Eppendorf (UKE)
Martinistr. 52, 20246 Hamburg, Germany

CV

Current Position

since 2022

W2-professor for Systemsnephrology and Cellular Immunity

University Training

1997 – 2005

Study of Medicine, Universities of Göttingen and Hamburg, Germany

Academic qualifications

2014

Habilitation in Internal Medicine / Nephrolgoy

2006

MD-thesis: ADP-ribolyslation of cell surface proteins on lymphocytes, (summa cum laude)

Previous professional career

Clinical postgraduate education:

2021

Board Certification Immunology

2018

Consultant (Oberarzt), III. Department of Medicine and Translational
Immunology, UKE Hamburg

2011

Board Certification Internal Medicine / Nephrology

2005 – 2018

Attending Physician, III. Department of Medicine, University Medical Center Hamburg- Eppendorf, Prof. Dr. Rolf A.K. Stahl and Prof. Dr. Tobias B. Huber

Scientific postgraduate education:

2014 – 2017

Gerok Position at the CRU 1192 “Immune-mediated Glomerular Diseases”

2013

Gerok Position at the Clinical Research Unit 228 (KFO 228) “Immunopathogenesis and Therapy of Glomerulonephritis”

2012

Research fellowship of the Forschungsförderungsfond für Medizin from the University Medical Center deanery

Selected awards and honors

2017

Hans-U. Zollinger Award (award from the German Society of Nephrology for the best immunological research work published in 2016 in nephrology)

2014

Dr. Martini-Award (award for the best research work published in 2013 at the UKE, oldest German award for medical research)

2013

Stipend from the German Society of Nephrology (DGfN) for the project “Plasticity of the TH17 immune response in experimental glomerulonephritis”

2011

Adalbert-Buding-Award

2006

Medac-Award for Immunology (Award for the best immunological MD thesis at the UKE)

2002

Stipent of the Werner Otto-Foundation

Selected publications

1.
2.
Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiß C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs CF.  Sci Immunol. 2021 Feb 23;6(56):eabf6692. 
3.
Krebs CF, Reimers D, Zhao Y, Paust HJ, Bartsch P, Nuñez S, Rosemblatt MV, Hellmig M, Kilian C, Borchers A, Enk LUB, Zinke M, Becker M, Schmid J, Klinge S, Wong MN, Puelles VG, Schmidt C, Bertram T, Stumpf N, Hoxha E, Meyer-Schwesinger C, Lindenmeyer MT, Cohen CD, Rink M, Kurts C, Franzenburg S, Koch-Nolte F, Turner JE, Riedel JH, Huber S, Gagliani N, Huber TB, Wiech T, Rohde H, Bono MR, Bonn S, Panzer U, Mittrücker HW.  Sci Immunol. 2020 Aug 7;5(50):eaba4163. 
4.
Marouf M, Machart P, Bansal V, Kilian C, Magruder DS, Krebs CF, Bonn S. Nat Commun. 2020 Jan 9;11(1):166. 
5.
Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RAK, Huber S, Turner JE, Panzer U. Immunity. 2016 Nov 15;45(5):1078-1092. 
6.
Krebs CF, Turner JE, Paust HJ, Kapffer S, Koyro T, Krohn S, Ufer F, Friese MA, Flavell RA, Stockinger B, Steinmetz OM, Stahl RA, Huber S, Panzer U.  J Immunol. 2016 Jul 15;197(2):449-57. 
7.
Krebs CF, Turner JE, Riedel JH, Panzer U. J Clin Invest. 2021 Jun 15;131(12):e150588. 
8.
Krebs CF, Schlitzer A, Kurts C. Kidney Int. 2020 May;97(5):842-844. 
9.
Krebs CF, Schmidt T, Riedel JH, Panzer U. Nat Rev Nephrol. 2017 Oct;13(10):647-659. 
10.
Seman M, Adriouch S, Scheuplein F, Krebs C, Freese D, Glowacki G, Deterre P, Haag F, Koch-Nolte F. Immunity. 2003 Oct;19(4):571-82. 

Funding

Martinistraße 52
Campus Research N27
20246 Hamburg Germany
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University Medical Center Hamburg - Eppendorf