— Jan-Eric Turner, MD
©Jan-Eric Turner
Lymphocytes of the innate and adaptive immune system are central regulators of the immune response in homeostasis and immune-mediated diseases. Recent studies have shown that specialized populations of innate lymphocytes and “innate-like” T cells that display features of both innate and adaptive immunity reside in the kidney where they contribute to production of cytokines and regulation of the local immune response. The contribution of these innate and innate-like lymphocyte populations to kidney injury and repair in immune-mediated renal diseases is still incompletely understood.
In the lab we use preclinical models of glomerulonephritis to study the function of kidney-resident innate and innate-like lymphocyte populations in kidney inflammation. These functional studies are complemented by a systems biology approach in which we perform high dimensional analysis of the molecular interactions of innate and innate-like lymphocytes with renal parenchymal cells in the healthy human kidney and in patients with glomerulonephritis.
Our studies are aimed at elucidating the role of innate and innate-like lymphocyte subsets in the renal immune response with a special focus on how these cells can be employed for targeted treatment approaches in patients with immune-mediated kidney diseases.
Principle Investigator
III. Department of Medicine & Hamburg Center for Translational Medicine, University Medical Center Hamburg-Eppendorf (UKE)
Martinistr. 52
20246 Hamburg, Germany
since 2015 | Principle Investigator “Innate Immune Regulation” Group, III. Department of Medicine, UKE |
2020 - 2023
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Managing Consultant, III. Department of Medicine, UKE |
2016 - 2023
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Consultant (Nephrology), III. Department of Medicine, UKE |
1998 - 2005
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Study of Medicine, Georg-August-Universität Göttingen, Germany |
2023 | Professorship, University of Hamburg |
2016 - 2020
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Habilitation and Venia Legendi for Internal Medicine and Nephrology, University of Hamburg |
2015 - 2021
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Principle Investigator of the Emmy-Noether-Research Group “Innate Lymphoid Cells in Renal Inflammation”, UKE |
2011 - 2013
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Postdoctoral Research Fellow, MRC National Institute for Medical Research, London, UK (Head: Dr. Brigitta Stockinger) |
2009 - 2012
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Co Principle Investigator, Clinical Research Unit 228, UKE |
2006 - 2011
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Clinician Scientist, III. Department of Medicine, UKE |
2001 - 2006
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MD Thesis, European Neuroscience Institute Göttingen, Germany |
Clinical postgraduate education:
2021
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Additional Training in Immunology (certified by the Chamber of Physicians Hamburg) |
2014
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Clinical Specialisation in Internal Medicine and Nephrology (certified by the Chamber of Physicians Hamburg) |
Scientific postgraduate education:
2011 - 2013
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Postdoctoral Research Fellow, MRC National Institute for Medical Research, London, UK (Head: Dr. Brigitta Stockinger) |
2006 - 2011
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Postdoctoral Research Fellow, III. Department of Medicine, UKE |
2018 - 2020
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Hans U. Zollinger Award for Immunologial Research in Nephrology, German Society of Nephrology |
2015 - 2021
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Emmy Noether Programme of the German Research Foundation |
2013
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Walter Hörl Fellowship of the German Kidney Foundation |
2011 - 2013
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Research Fellowship of the German Research Foundation |
1. | Gnirck AC, Philipp MS, Waterhölter A, Wunderlich M, Shaikh N, Adamiak V, Henneken L, Kautz T, Xiong T, Klaus D, Tomczyk P, Al-Bahra MM, Menche D, Walkenhorst M, Lantz O, Willing A, Friese MA, Huber TB, Krebs CF, Panzer U, Kurts C, Turner JE. Nat Commun. 2023 Nov 15;14(1):7372. |
2. | Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites. |
3. | MAIT cells in immune-mediated tissue injury and repair. |
4. | Conventional NK cells and ILC1s do not influence pathogenesis of experimental glomerulonephritis. |
5. | Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients. |
6. | Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy. |
7. | IL-33-mediated expansion of type 2 Innate Lymphoid Cells protects from progressive glomerulosclerosis |
8. | Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney |
9. | IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation |
10. | Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses |
Martinistraße 52
Campus Research N27
20246 Hamburg Germany