— Jan-Eric Turner, MD
©Jan-Eric Turner
Lymphocytes of the innate and adaptive immune system are central regulators of the immune response in homeostasis and immune-mediated diseases. Recent studies have shown that specialized populations of innate lymphocytes and “innate-like” T cells, that display features of both innate and adaptive immunity, reside in the kidney where they contribute to production of cytokines and regulation of the local immune response. The contribution of these innate and innate-like lymphocyte populations to kidney injury and repair in immune-mediated renal diseases is still incompletely understood.
In the lab we use preclinical models of glomerulonephritis to study the function of kidney-resident innate and innate-like lymphocyte populations in kidney inflammation. These functional studies are complemented by a systems biology approach, in which we perform high dimensional analysis of the molecular interactions of innate and innate-like lymphocytes with renal parenchymal cells in the healthy human kidney and in patients with glomerulonephritis.
Our studies are aimed at elucidating the role of innate and innate-like lymphocyte subsets in the renal immune response with a special focus on how these cells can be employed for targeted treatment approaches in patients with immune-mediated kidney diseases.
Managing Consulant, III. Department of Medicine
Principle Investigator
III. Department of Medicine & Hamburg Center for Translational Medicine, University Medical Center Hamburg-Eppendorf (UKE)
Martinistr. 52
20246 Hamburg, Germany
since 2020 - 2020
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Managing Consulant, III. Department of Medicine, UKEE |
since 2020
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Board member, Hamburg Center for Translational Medicine, UKE |
since 2016
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Consultant (Nephrology), III. Department of Medicine, UKE |
since 2015
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Principle Investigator “Innate Immune Regulation” Group, III. Department of Medicine, UKE |
1998 - 2005
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Study of Medicine, Georg-August-Universität Göttingen, Germany |
2016 - 2020
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Habilitation and Venia Legendi for Internal Medicine and Nephrology, University of Hamburg |
2015 - 2021
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Principle Investigator of the Emmy-Noether-Research Group “Innate Lymphoid Cells in Renal Inflammation”, UKE |
2011 - 2013
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Postdoctoral Research Fellow, MRC National Institute for Medical Research, London, UK (Head: Dr. Brigitta Stockinger) |
2009 - 2012
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Co Principle Investigator, Clinical Research Unit 228, UKE |
2006 - 2011
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Clinician Scientist, III. Department of Medicine, UKE |
2001 - 2006
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MD Thesis, European Neuroscience Institute Göttingen, Germany |
Clinical postgraduate education:
2021
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Additional Training in Immunology (certified by the Chamber of Physicians Hamburg) |
2014
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Clinical Specialisation in Internal Medicine and Nephrology (certified by the Chamber of Physicians Hamburg) |
Scientific postgraduate education:
2011 - 2013
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Postdoctoral Research Fellow, MRC National Institute for Medical Research, London, UK (Head: Dr. Brigitta Stockinger) |
2006 - 2011
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Postdoctoral Research Fellow, III. Department of Medicine, UKE |
2018 - 2020
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Hans U. Zollinger Award for Immunologial Research in Nephrology, German Society of Nephrology |
2015 - 2021
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Emmy Noether Programme of the German Research Foundation |
2013
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Walter Hörl Fellowship of the German Kidney Foundation |
2011 - 2013
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Research Fellowship of the German Research Foundation |
1. | Conventional NK cells and ILC1s do not influence pathogenesis of experimental glomerulonephritis. |
2. | Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients. |
3. | Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy. |
4. | Endogenous IL-22 is dispensable for experimental glomerulonephritis. |
5. | T cell-derived IFN-γ downregulates protective group 2 innate lymphoid cells in murine lupus erythematosus |
6. | IL-33-mediated expansion of type 2 Innate Lymphoid Cells protects from progressive glomerulosclerosis |
7. | Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney |
8. | IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation |
9. | Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses |
10. | IL-17A production by renal gammadelta T cells promotes kidney injury in crescentic GN |
The Collaborative Research Center (SFB) 1192 "Immune-Mediated Glomerular Diseases" of the ...
UKE Paper of the Month (PoM) September 2023
Martinistraße 52
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