HCKH - PI Florian Grahammer - Hamburg Center for Kidney Health

Laboratory for glomerular biology and transplantation medicine

Florian Grahammer

Florian Grahammer

Mission Statement

“Deciphering glomerular biology and the renal filtration barrier to gain pathomechanistic insights into glomerular diseases”

— Florian Grahammer, MD

Team Members

Post Doc

Claudio Rodriguez Gonzalez

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Clinician Scientist

Bernhard Christian Dumoulin, MD

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Post Doc

Badr Khbouz, PhD

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MD Student

Huagang Lin

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MD student

Botho Schneider

MD Student

Hui Wu

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Technician

Nina Ziegert

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Research

Zoom

Our aim is to elucidate the processes that maintain and regulate renal filtration. The unique structure of the glomerular filtration barrier guarantees a lifelong filtration process without loosing cells or albumin. We have developed tools to characterize specific parts of this process in order to better understand physiological and pathophysiological mechanisms. Most recently we introduced a new structural model of the slit-diaphragm and were able to partly decipher the molecular composition of the building blocks of this extraordinary cell-cell contact. We are currently exploring the signaling properties of this structure and investigating the effects of certain signaling cascades for glomerular diseases.

Florian Grahammer, MD

III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE)
Martinistr. 52
20246 Hamburg, Germany

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CV

Current Position

since 2020	PI CRC 1192 Immune mediated glomerular diseases
since 2018	Director of the University Transplant Center, University Medical Center Hamburg-Eppendorf
since 2017	Deputy Head of the III. Department of Medicine, University Medical Center Hamburg-Eppendorf

University Training

1996 - 2003

Medical School at the Universities of Freiburg, Leeds/GB and Tübingen

Academic qualifications

2018	Habilitation at the University of Hamburg
2017	Habilitation at the University of Freiburg “Adaptive mechanisms of epithelial injury”
2003	Doctoral Thesis (MD) at the University of Freiburg “Role of the K⁺-channel KvLQT1 and its regulatory subunits for epithelial function in vivo”

Previous professional career

Clinical postgraduate education:
since 2012	Attending Physician
since 2010	German Board Certification for Emergency Medicine (2010), Internal Medicine (2011), Nephrology (2014), Transplantation Medicine (2021)
2008 - 2009	Fellowship Department of Medicine, Renal Division University Hospital Freiburg
2005 - 2008	Residency Department of Medicine, Renal Division University Hospital Freiburg
Scientific postgraduate education:
since 2020	PI CRC1192 Immune mediated glomerular diseases Research Group Leader
2015 - 2020	PI CRC1140 KIDGEM Research Group Leader
2012 - 2014	PI KFO201, Junior Research Group Leader
2010 - 2012	Else-Kröner Memorial Scholarship
2009 - 2010	Postdoctoral Fellow, Renal Division University Hospital Freiburg
2003 - 2005	Postdoctoral Fellow, Department of Physiology, Eberhard-Karls-University of Tübingen

Selected awards and honors

2023	Honorary Scientific Prize (Wissenschaftlichen Ehrenpreis) of the German Society of Nephrology
2016	Carl-Ludwig Award of the German Society of Nephrology
2004	Young Nephrologist Award of the German Renal Society

Selected publications

1.	Loss of the collagen IV modifier prolyl 3-hydroxylase 2 causes thin basement membrane nephropathy. Aypek H, Krisp C, Lu S, Liu S, Kylies D, Kretz O, Wu G, Moritz M, Amann K, Benz K, Tong P, Hu ZM, Alsulaiman SM, Khan AO, Grohmann M, Wagner T, Müller-Deile J, Schlüter H, Puelles VG, Bergmann C, Huber TB, Grahammer F. J Clin Invest. 2022 May 2;132(9):e147253.
2.	P2Y2R Signaling Is Involved in the Onset of Glomerulonephritis. Rennert L, Zschiedrich S, Sandner L, Hartleben B, Cicko S, Ayata CK, Meyer C, Zech A, Zeiser R, Huber TB, Idzko M, Grahammer F. Front Immunol. 2018 Jul 16;9:1589.
3.	A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes. Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB. Cell Rep. 2018 May 22;23(8):2495-2508.
4.	A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes. Grahammer F, Wigge C, Schell C, Kretz O, Patrakka J, Schneider S, Klose M, Kind J, Arnold SJ, Habermann A, Bräuniger R, Rinschen MM, Völker L, Bregenzer A, Rubbenstroth D, Boerries M, Kerjaschki D, Miner JH, Walz G, Benzing T, Fornoni A, Frangakis AS, Huber TB. JCI Insight. 2016 Jun 16;1(9):e86177.
5.	mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells. Grahammer F, Ramakrishnan SK, Rinschen MM, Larionov AA, Syed M, Khatib H, Roerden M, Sass JO, Helmstaedter M, Osenberg D, Kühne L, Kretz O, Wanner N, Jouret F, Benzing T, Artunc F, Huber TB, Theilig F. J Am Soc Nephrol. 2017 Jan;28(1):230-241.
6.	mTORC2 critically regulates renal potassium handling. Grahammer F, Nesterov V, Ahmed A, Steinhardt F, Sandner L, Arnold F, Cordts T, Negrea S, Bertog M, Ruegg MA, Hall MN, Walz G, Korbmacher C, Artunc F, Huber TB. J Clin Invest. 2016 May 2;126(5):1773-82.
7.	mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Grahammer F, Haenisch N, Steinhardt F, Sandner L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg MA, Hall MN, Moulin P, Busch H, Boerries M, Walz G, Artunc F, Huber TB. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):E2817-26.
8.	The podocyte slit diaphragm--from a thin grey line to a complex signalling hub. Grahammer F, Schell C, Huber TB. Nat Rev Nephrol. 2013 Oct;9(10):587-98.