Laboratory for glomerular biology and transplantation medicine

Florian Grahammer

Mission Statement

“Deciphering glomerular biology and the renal filtration barrier to gain pathomechanistic insights into glomerular diseases”

Florian Grahammer, MD

Team Members

Post Doc

Claudio Rodriguez Gonzalez

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Clinician Scientist

Bernhard Christian Dumoulin, MD

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Post Doc

Badr Khbouz, PhD

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MD Student

Huagang Lin

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MD student

Botho Schneider

MD Student

Hui Wu

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Technician

Nina Ziegert

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Research

© Grahammer F. et al. JCI Insight 2016

Our aim is to elucidate the processes that maintain and regulate renal filtration. The unique structure of the glomerular filtration barrier guarantees a lifelong filtration process without loosing cells or albumin. We have developed tools to characterize specific parts of this process in order to better understand physiological and pathophysiological mechanisms. Most recently we introduced a new structural model of the slit-diaphragm and were able to partly decipher the molecular composition of the building blocks of this extraordinary cell-cell contact. We are currently exploring the signaling properties of this structure and investigating the effects of certain signaling cascades for glomerular diseases.

Florian Grahammer, MD

III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE)
Martinistr. 52
20246 Hamburg, Germany

CV

Current Position

since 2020

PI CRC 1192 Immune mediated glomerular diseases

since 2018

Director of the University Transplant Center, University Medical Center Hamburg-Eppendorf

since 2017

Deputy Head of the III. Department of Medicine, University Medical Center Hamburg-Eppendorf

University Training

1996 - 2003

Medical School at the Universities of Freiburg, Leeds/GB and Tübingen

Academic qualifications

2018

Habilitation at the University of Hamburg

2017

Habilitation at the University of Freiburg “Adaptive mechanisms of epithelial injury”

2003

Doctoral Thesis (MD) at the University of Freiburg “Role of the K+-channel KvLQT1 and its regulatory subunits for epithelial function in vivo

Previous professional career

Clinical postgraduate education:

since 2012

Attending Physician

since 2010

German Board Certification for Emergency Medicine (2010), Internal Medicine (2011), Nephrology (2014), Transplantation Medicine (2021)

2008 - 2009

Fellowship Department of Medicine, Renal Division University Hospital Freiburg

2005 - 2008

Residency Department of Medicine, Renal Division University Hospital Freiburg

Scientific postgraduate education:

since 2020

PI CRC1192 Immune mediated glomerular diseases Research Group Leader

2015 - 2020

PI CRC1140 KIDGEM Research Group Leader

2012 - 2014

PI KFO201, Junior Research Group Leader

2010 - 2012

Else-Kröner Memorial Scholarship

2009 - 2010

Postdoctoral Fellow, Renal Division University Hospital Freiburg

2003 - 2005

Postdoctoral Fellow, Department of Physiology, Eberhard-Karls-University of Tübingen

Selected awards and honors
2023 Honorary Scientific Prize (Wissenschaftlichen Ehrenpreis) of the German Society of Nephrology

2016

Carl-Ludwig Award of the German Society of Nephrology

2004

Young Nephrologist Award of the German Renal Society

Selected publications

1.
Aypek H, Krisp C, Lu S, Liu S, Kylies D, Kretz O, Wu G, Moritz M, Amann K, Benz K, Tong P, Hu ZM, Alsulaiman SM, Khan AO, Grohmann M, Wagner T, Müller-Deile J, Schlüter H, Puelles VG, Bergmann C, Huber TB, Grahammer F. J Clin Invest. 2022 May 2;132(9):e147253.
2.
Rennert L, Zschiedrich S, Sandner L, Hartleben B, Cicko S, Ayata CK, Meyer C, Zech A, Zeiser R, Huber TB, Idzko M, Grahammer F. Front Immunol. 2018 Jul 16;9:1589.
3.
Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB. Cell Rep. 2018 May 22;23(8):2495-2508.
4.
Grahammer F, Wigge C, Schell C, Kretz O, Patrakka J, Schneider S, Klose M, Kind J, Arnold SJ, Habermann A, Bräuniger R, Rinschen MM, Völker L, Bregenzer A,
Rubbenstroth D, Boerries M, Kerjaschki D, Miner JH, Walz G, Benzing T, Fornoni A, Frangakis AS, Huber TB. JCI Insight. 2016 Jun 16;1(9):e86177.
5.
Grahammer F, Ramakrishnan SK, Rinschen MM, Larionov AA, Syed M, Khatib H, Roerden M, Sass JO, Helmstaedter M, Osenberg D, Kühne L, Kretz O, Wanner N, Jouret F, Benzing T, Artunc F, Huber TB, Theilig F. J Am Soc Nephrol. 2017 Jan;28(1):230-241.
6.
Grahammer F, Nesterov V, Ahmed A, Steinhardt F, Sandner L, Arnold F, Cordts T, Negrea S, Bertog M, Ruegg MA, Hall MN, Walz G, Korbmacher C, Artunc F, Huber TB.  J Clin Invest. 2016 May 2;126(5):1773-82.
7.
Grahammer F, Haenisch N, Steinhardt F, Sandner L, Roerden M, Arnold F, Cordts T, Wanner N, Reichardt W, Kerjaschki D, Ruegg MA, Hall MN, Moulin P, Busch H, Boerries M, Walz G, Artunc F, Huber TB. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):E2817-26.
8.
Grahammer F, Schell C, Huber TB. Nat Rev Nephrol. 2013 Oct;9(10):587-98.

Funding

News

Open Positions

We are looking for highly motivated and ambitious postdocs, PhD students, master students, and student research assistants.

July 9, 2024 | Seminar
Open Positions

We are constantly looking for highly motivated, talented and team-oriented researchers to join our team ...

Martinistraße 52
Campus Research N27
20246 Hamburg Germany
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University Medical Center Hamburg - Eppendorf