Mission Statement

"Deciphering organ-specific immune development to promote immune-mediated tissue regeneration of organs and host-defense responses against pathogens"

— Madeleine Bunders, MD/PhD

Team Members

Project Manager

Tanja Barkhausen, PhD

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Post Doc

Martin Baumdick, PhD

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Post Doc

Malte Borggrewe, PhD

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Post Doc

Markus Flosbach, PhD

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Technician

Heike Hildebrandt

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Research

© Science Immunology

Recent studies by our group have shown that organ specific immune development in humans is a highly dynamic process. Furthermore, early in life immune responses are directed towards mediating tissue development. We demonstrated that memory CD4+ T cells in children regulate intestinal development. However, further skewing of tissue regenerative immune responses can contribute to impaired tissue regeneration, inflammation and lack of control of infections. The group focusses on discovery of the mechanisms mediating communication between immune cells and tissue cells that regulate immune development and when dysregulated contribute to infectious and inflammatory diseases in children. To this end, we have developed in vitro organoid-immune cell models. These novel in vitro models mimic tissue in 3D and allow to study interactions between human tissue and immune cells in healthy human development and diseases to identify targets to develop new medical strategies to restore tissue homeostasis and promote healthy organ development.

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Madeleine Bunders, MD/PhD

Head of the Division for Regenerative Medicine and Immunology (Heisenberg)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE)

Leibniz Institute of Virology (LIV), Hamburg
Martinistr. 52
20246 Hamburg, Germany

CV

Current Position
since 2023

Head of the Division for Regenerative Medicine and Immunology (Heisenberg), III. Department of Medicine, University Medical Center Hamburg-Eppendorf

University Training
1996 - 2004

Study of Human Medicine, University of Amsterdam, The Netherlands

Academic qualifications
2013- 2020

Ph.D., University of Amsterdam, The Netherlands

2004

M.D., University of Amsterdam, The Netherlands

Previous professional career

Clinical postgraduate education:

2015

Specialist in Pediatrics, Amsterdam University Medical Centre, Amsterdam, The Netherlands

Scientific postgraduate education:

2016 - 2021

Junior Group Leader, Department Virus Immunology, Leibniz Institute for Experimental Virology, Germany

2015 - 2020

Junior Group Leader, Department of Pediatrics, Amsterdam University Medical Centre, The Netherlands

2014 - 2015

Postdoctoral Researcher, Department of Pediatrics, Amsterdam University Medical Centre, The Netherlands

Selected awards and honors
2013 - 2020

Ph.D. Award, Dutch Society for Pediatric Immunology and Infectious Diseases

2006

Award for M.D.-Ph.D. trajectory with a specialization in Pediatrics, by the Dutch Research Council

2004

Exchange Student Award, Royal Dutch Academy for Sciences

Selected publications

1.
JMöller KJ, Wegner L, Malsy J, Baumdick ME, Borggrewe M, Jordan-Paiz A, Jung JM, Martrus G, Kretschmer P, Sagebiel AF, Schreurs R, Hagen SH, Burmester G, Clauditz TS, Pals ST, Boettcher M, Melling N, Sauter G, Tomuschat C, Königs I, Schumacher U, Altfeld M, Bernink JH, Perez D, Reinshagen K, Bunders MJ.  Mucosal Immunol. 2023 Apr 28:S1933-0219(23)00030-2. 
2.
Jung JM, Ching W, Baumdick ME, Hofmann-Sieber H, Bosse JB, Koyro T, Möller KJ, Wegner L, Niehrs A, Russu K, Ohms M, Zhang W, Ehrhardt A, Duisters K, Spierings E, Hölzemer A, Körner C, Jansen SA, Peine S, Königs I, Lütgehetmann M, Perez D, Reinshagen K, Lindemans CA, Altfeld M*, Belderbos M*, Dobner T*, Bunders MJ*. Science Immunology. 2021 Sep 17; 6(63).
3.
Stein MC, Braun F, Krebs CF, Bunders MJ. Cell Tissue Res. 2021 Aug;385(2).
4.
Schreurs RRCE, Baumdick ME, Drewniak A, Bunders MJ. Star Protocols Cell Press. 2021 May 14;2(2).
5.
Schreurs RRCE, Sagebiel AF, Steinert FL, Highton AJ, Klarenbeek PL, Drewniak A, Bakx R, The SML, Ribeiro CMS, Perez D, Reinshagen K, Geijtenbeek TBH, van Goudoever JB, Bunders MJ. Mucosal Immunology. 2021 May 14(3).
6.
Sagebiel AF, Steinert F, Lunemann S, Körner C, Schreurs RRCE, Altfeld M, Perez D, Reinshagen K, Bunders MJ. Nat Commun. 2019 Feb 28;10(1).
7.
Schreurs RRCE, Baumdick ME*, Sagebiel AF*, Kaufmann M, Mokry M, Klarenbeek PL, Schaltenberg N, Steinert FL, van Rijn JM, Drewniak A, The SML, Bakx R, Derikx JPM, de Vries N, Corpeleijn WE, Pals ST, Gagliani N, Friese MA, Middendorp S, Nieuwenhuis EES, Reinshagen K, Geijtenbeek TBH, van Goudoever JB, Bunders MJ. Immunity. 2019 Feb 19;50(2).
8.
Schreurs RRCE, Drewniak A, Bakx R, Corpeleijn WE, Geijtenbeek THB, van Goudoever JB, Bunders MJ. J Immunol Methods. 2017 Jun;445.
9.
Schoeman JC, Moutloatse GP, Harms AC, Vreeken RJ, Scherpbier HJ, Van Leeuwen L, Kuijpers TW, Reinecke CJ, Berger R, Hankemeier T*, Bunders MJ*. J Infect Dis. 2017 Aug 15;216(4).
10.
Bunders MJ, van der Loos CM, Klarenbeek PL, van Hamme JL, Boer K, Wilde JCH, de Vries N, van Lier RAW, Kootstra N, Pals ST, Kuijpers TW. Blood. 2012 Nov 22 120(22).

Funding

Martinistraße 52
Campus Research N27
20246 Hamburg Germany
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University Medical Center Hamburg - Eppendorf