— Stefan Bonn, PhD
Focal segmental glomerulosclerosis (FSGS) is a major glomerular cause of end stage renal disease. FSGS represents a pattern of response to injury, subsequent damage and loss of podocytes regardless of the underlying etiology. It is hypothesized that the primary form of FSGS is caused by an unknown circulating factor that leads to disturbed cell-cell-interaction and often to early and devastating recurrence after kidney transplantation. Modeling global communications among cells requires accurate representations of cell-cell signaling links and effective systems-level analyses. With the advent of single cell sequencing (scRNA-seq), it is possible to estimate cell heterogeneity at a high resolution allowing detailed cataloguing of cell types and prediction of cellular differentiation trajectories and communication. The goal of this project is to elucidate the pathologic transformations occurring in (recurrent) FSGS.
since 2017 | Professor and Director of the Institute of Medical Systems Biology at the Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, Germany |
2008 - 2012- 2020
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Postdoctoral Fellow, European Molecular Biology Laboratory (EMBL). Advisors: Eileen Furlong, PhD & Ann-Claude Gavin, PhD |
2004 - 2007
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PhD Thesis, University of Heidelberg, Max-Planck-Institute for Medical Research (MPI-MR), Heidelberg, Germany. Advisor: Prof. Dr. Peter Seeburg |
2004
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Master thesis, Universität Bayreuth, Deutsches Krebsforschungszentrum, Heidelberg, Deutschland |
Scientific postgraduate education:
2017 - 2021 | Senior researcher, German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany |
2012 - 2017
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Head of the genomic core, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany |
2012 - 2017
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Independent Research Group Leader, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany |
2018 - 2020
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Member of the advisory board of the Center for Biostructural Imaging in Neurodegeneration, Göttingen, Germany |
2017
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Member of the advisory board of Genevention GmbH |
2017
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Invitation to the symposium “Sino-German Frontiers of Science” of the Alexander von Humboldt-Society and the Chinese Academy of Sciences |
2011 - 2012
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DFG Scholarship for postdocs |
2008 - 2011
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EMBL interdisciplinary postdoctoral fellowship (eIPOD) |
2004 - 2012
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EMBO and Marie-Curie travel grants for advanced training in bioinformatics |
1. | Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development. |
2. | Oasis: online analysis of small RNA deep sequencing data. |
3. | DNA methylation changes in plasticity genes accompany the formation and maintenance of memory. . |
4. | TAp73 is a central transcriptional regulator of airway multiciliogenesis. |
5. | The landscape of human mutually exclusive splicing. |
6. | OTTO: a new strategy to extract mental disease-relevant combinations of GWAS hits from individuals. |
7. | Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice. |
8. | Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia. |
9. | Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions. |
10. | Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy. |
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