Mühlig

Laboratory for Pediatric Nephrology Research

Anne Mühlig

Anne Mühlig

Mission Statement

“Uncover the molecular and sex-specific mechanisms underlying pediatric kidney diseases, to enable the development of precise, individualized therapies”

— Dr. med. Anne Mühlig

Team Members

Clinician Scientist

Elena Jost

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MD student

Charlotte Kolck

MD student

Josephine Quaas

MD student

Emily Schepke

Research

Our research group investigates the molecular mechanisms underlying the development and progression of pediatric kidney diseases. A particular focus lies on sex-specific differences and the identification and characterization of differentially regulated pathways.We are especially interested in the role of the immune system and its sex-specific regulation in disease processes. To address these questions, we combine established mouse models and cell culture systems with state-of-the-art omics technologies and standardized molecular biological methods. Our goal is to uncover novel molecular mechanisms and translate these findings into druggable targets, ultimately enabling the development of individualized therapies for children with kidney diseases.

Anne Mühlig, MD

Junior Group Leader

Department of Pediatrics, University Medical Center Hamburg-Eppendorf (UKE)
Martinistr. 52
20246 Hamburg, Germany

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CV

Current Position

since 2025	Principal Investigator in CRC/TR 422 Project A4
since 2024	Principal Investigator in CRC1192 Project B8
since 2011	Physician, Department of Pediatrics, University Medical Center Hamburg- Eppendorf

University Training

2001 - 2007

Study of Medicine, Medical University Innsbruck, Austria

Academic qualifications

20152020	Board Certification for Pediatrics
20152020	PhD-Thesis: Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Germany
2007	MD Thesis:  Department of Pediatrics, Medical University Innsbruck, Austria

Previous professional career

Clinical postgraduate education:

2011 - 2015	Attending Physician for Pediatrics, University Medical Center Hamburg- Eppendorf, Germany
2007 - 2011	Attending Physician for Pediatrics, Medical University Innsbruck, Austria

Selected awards and honors

2024 - 2020	Grundlagen-Forschungspreis der Gesellschaft für Pädiatrische Nephrologie
2023	Dr. Martini Preis, University Medical Center Hamburg-Eppendorf

Selected publications

1.	Anti-nephrin antibodies in pediatric nephrotic syndrome: a new paradigm. Mühlig AK, Hengel FE, Oh J, Tomas NM, Huber TB. Pediatr Nephrol. 2026 Apr 23. doi: 10.1007/s00467-026-07292-9.
2.	A New Hope for Treating Podocytopathies: Emerging Role of Anti-Nephrin Antibody. Liaukouskaya N, Hengel FE, Mühlig A, Tomas NM, Huber TB. Clin J Am Soc Nephrol. 2026 Jan 21. doi: 10.2215/CJN.0000001008.
3.	New insights into the immune functions of podocytes: the role of complement. Bruno V, Mühlig AK, Oh J, Licht C. Mol Cell Pediatr. 2023 Apr 15;10(1):3.
4.	Non-invasive Diagnosis of Antinephrin-Associated Podocytopathy. Hengel FE, Chong MCZ, Leung WY, Dehde S, Mühlig A, Janneck M, Wu HHL, Huber TB, Ponnusamy A, Tomas NM. Kidney Int Rep. 2025 May 12;10(8):2800-2804.
5.	Optimized protocol for the multiomics processing of cryopreserved human kidney tissue. Gies SE, Hänzelmann S, Kylies D, Lassé M, Lagies S, Hausmann F, Khatri R, Zolotarev N, Poets M, Zhang T, Demir F, Billing AM, Quaas J, Meister E, Engesser J, Mühlig AK, Lu S, Liu S, Chilla S, Edenhofer I, Czogalla J, Braun F, Kammerer B, Puelles VG, Bonn S, Rinschen MM, Lindenmeyer M, Huber TB. Am J Physiol Renal Physiol. 2024 Nov 1;327(5):F822-F844.
6.	Synuclein α accumulation mediates podocyte injury in Fabry nephropathy. Braun F, Abed A, Sellung D, Rogg M, Woidy M, Eikrem O, Wanner N, Gambardella J, Laufer SD, Haas F, Wong MN, Dumoulin B, Rischke P, Mühlig AK, Sachs W, von Cossel K, Schulz K, Muschol N, Gersting SW, Muntau AC, Kretz O, Hahn O, Rinschen MM, Mauer M, Bork T, Grahammer F, Liang W, Eierhoff T, Römer W, Hansen A, Meyer-Schwesinger C, Iaccarino G, Tøndel C, Marti HP, Najafian B, Puelles VG, Schell C, Huber TB. J Clin Invest. 2023 Apr 4:e157782.
7.	Precision nephrology: from molecular diagnostics to an individualized therapy. Mühlig AK, Oh J, Huber TB. Kidney Int. 2023 Mar;103(3):464-466.
8.	The calcium-sensing receptor stabilizes podocyte function in proteinuric humans and mice. Mühlig AK, Steingröver J, Heidelbach HS, Wingerath M, Sachs W, Hermans-Borgmeyer I, Meyer-Schwesinger C, Choi HY, Lim BJ, Patry C, Hoffmann GF, Endlich N, Bracke K, Weiß M, Guse AH, Lassé M, Rinschen M, Braun F, Huber TB, Puelles VG, Schmitt CP, Oh J. Kidney Int. 2022 Mar 7:S0085-2538(22)00175-2.
9.	Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H. Mühlig AK, Keir LS, Abt JC, Heidelbach HS, Horton R, Welsh GI, Meyer-Schwesinger C, Licht C, Coward RJ, Fester L, Saleem MA, Oh J. Front Immunol. 2020 Aug 14;11:1833.
10.	Levamisole in Children with Idiopathic Nephrotic Syndrome: Clinical Efficacy and Pathophysiological Aspects. Mühlig AK, Lee JY, Kemper MJ, Kronbichler A, Yang JW, Lee JM, Shin JI, Oh J. J Clin Med. 2019 Jun 16;8(6):860.