Transcriptional and clonal characterization of cytotoxic T cells in crescentic glomerulonephritis
March 2023 | New Publication
Mueller A et al., J Am Soc Nephrol 2023
This collaborative work from several groups of the Hamburg Center for Translational Immunology identifies activated, clonally expanded T cells with a cytotoxic gene expression profile in the kidneys of patients with ANCA-associated glomerulonephritis and demonstrates a pathogenic role of clonally expanded CD8+ T cells expressing granzyme B.
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