CD4+ T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12
March 2023 | New Publication
Paust HJ et al., Sci Transl Med 2023
This work from the Hamburg Center for Translational Immunology identifies a novel population of GM-CSF producing T cells in glomerulonephritis. These cells activate monocyte-derived cells to generate matrix metalloproteinase 12, which leads to a cleavage of the glomerular basement membrane.
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