Cyclin-dependent kinase 4 drives cystic kidney disease in the absence of mTORC1 signaling activity
August 2024 | New Publication
Grahammer F et al., Kidney Int. 2024
The findings indicate that cystic kidneys rapidly adopt bypass mechanisms typically observed in drug resistant cancers. Thus, future clinical trials need to consider combinatorial or sequential therapies to improve therapeutic efficacy in patients with cystic kidney disease.
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