Progression of chronic kidney disease (CKD) is associated with impairment of erythropoietin (Epo) secretion and patients develop a renal anaemia that needs to be treated with erythropoiesis stimulating agents (ESAs). NephrESA is a mechanism-based multiscale model. which simulates EPO interactions in the human body. The integration and different combinations of specific submodels (inflam, iron, thromb) are utilized to retrospectively analyse the clinical data to establish a minimal model structure to optimize anaemia treatment for the individual CKD patient and particularly reduce the risk of thrombovascular events.


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University Medical Center Hamburg - Eppendorf