Urinary proteome analysis for the prediction of type, extent, prognosis, and therapeutic response of acute and chronic kidney diseases

Can urinary peptides guide intervention in chronic kidney diseases towards personalized intervention?

For accurate diagnosis of kidney diseases a renal biopsy is currently indispensable. Biopsy allows classification of the disease but, especially in slow progressing non-nephrotic diseases, is not very helpful in the judgement of prognosis and therapeutic response. The aim of UPTAKE is to test the ability of the urinary proteome analysis to substitute for renal biopsy, to predict extent of fibrosis and to predict response to therapy.

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University Medical Center Hamburg - Eppendorf