Lassé et al., Nat Commun 2023 was selected UKE Paper of the Month (PoM) September 2023:
This is indeed an important UKE study as it takes the non-animal ("3R UKE") approach to kidney research to a new level. Organoids have the potential to model human disease in complex organs including the kidney. However, their function largely depends on the proteins expressed, as well as the dynamic responses towards inflammatory stimuli. This is the first time that a comprehensive atlas of human kidney organoids was generated, showcasing cell-type responses, secretome and protein dynamics, and direct relevance to patients with proteinuric kidney disease. The generated map on both proteome and single-cell transcriptome level map extends organoid modelling potential, but also shows limitations of this model system that will be able to guide future research.
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Nat Commun - An integrated organoid omics map extends modeling potential of kidney disease