Metabolic Communication by SGLT2 Inhibition
December 2023 | New Publication
Billing AM et al., Circulation 2023
The Team of Markus Rinschen shows that SGLT2i reduced microbiome formation of uremic toxins such as p-cresol sulfate and thereby their body exposure and need for renal detoxification, which, combined with direct kidney effects of SGLT2i, including less proximal tubule glucotoxicity and a broad downregulation of apical transporters (including sodium, amino acid, and urate uptake), provides a metabolic foundation for kidney and cardiovascular protection.
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