Meister

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  • Mailadresse: Elisabeth Meister, MD
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  • Datum + Kategorie: Clinician Scientist

Mühlig

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  • Mailadresse: Anne Mühlig, MD/PhD
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  • Datum + Kategorie: Post Doc

Anne Mühlig

Laboratory for Pediatric Nephrology Research

Mission Statement

“Uncover the molecular and sex-specific mechanisms underlying pediatric kidney diseases, to enable the development of precise, individualized therapies”

— Dr. med. Anne Mühlig

Team Members

Research

Our research group investigates the molecular mechanisms underlying the development and progression of pediatric kidney diseases. A particular focus lies on sex-specific differences and the identification and characterization of differentially regulated pathways.We are especially interested in the role of the immune system and its sex-specific regulation in disease processes. To address these questions, we combine established mouse models and cell culture systems with state-of-the-art omics technologies and standardized molecular biological methods. Our goal is to uncover novel molecular mechanisms and translate these findings into druggable targets, ultimately enabling the development of individualized therapies for children with kidney diseases.

Anne Mühlig, MD

Junior Group Leader

Department of Pediatrics, University Medical Center Hamburg-Eppendorf (UKE)
Martinistr. 52
20246 Hamburg, Germany

CV

  • Current Position

    since 2025
    		 Principal Investigator in CRC/TR 422 Project A4
    since 2024
    		 Principal Investigator in CRC1192 Project B8
    since 2011 Physician, Department of Pediatrics, University Medical Center Hamburg- Eppendorf

  • University Training

    2001 - 2007

    Study of Medicine, Medical University Innsbruck, Austria

  • Academic qualifications

    20152020

    Board Certification for Pediatrics

    20152020

    		 PhD-Thesis: Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Germany
    2007

    MD Thesis: 
Department of Pediatrics, Medical University Innsbruck, Austria

  • Previous professional career

    Clinical postgraduate education:

    2011 - 2015

    Attending Physician for Pediatrics, University Medical Center Hamburg- Eppendorf, Germany
    2007 - 2011

    Attending Physician for Pediatrics, Medical University Innsbruck, Austria
     

  • Selected awards and honors

    2024 - 2020

    Grundlagen-Forschungspreis der Gesellschaft für Pädiatrische Nephrologie
    2023

    Dr. Martini Preis, University Medical Center Hamburg-Eppendorf

Selected publications

1.
Mühlig AK, Hengel FE, Oh J, Tomas NM, Huber TB. Pediatr Nephrol. 2026 Apr 23. doi: 10.1007/s00467-026-07292-9. 
2.
Liaukouskaya N, Hengel FE, Mühlig A, Tomas NM, Huber TB. Clin J Am Soc Nephrol. 2026 Jan 21. doi: 10.2215/CJN.0000001008. 
3.
Bruno V, Mühlig AK, Oh J, Licht C. Mol Cell Pediatr. 2023 Apr 15;10(1):3. 
4.
Hengel FE, Chong MCZ, Leung WY, Dehde S, Mühlig A, Janneck M, Wu HHL, Huber TB, Ponnusamy A, Tomas NM. Kidney Int Rep. 2025 May 12;10(8):2800-2804. 
5.
Gies SE, Hänzelmann S, Kylies D, Lassé M, Lagies S, Hausmann F, Khatri R, Zolotarev N, Poets M, Zhang T, Demir F, Billing AM, Quaas J, Meister E, Engesser J, Mühlig AK, Lu S, Liu S, Chilla S, Edenhofer I, Czogalla J, Braun F, Kammerer B, Puelles VG, Bonn S, Rinschen MM, Lindenmeyer M, Huber TB. Am J Physiol Renal Physiol. 2024 Nov 1;327(5):F822-F844. 
6.
Braun F, Abed A, Sellung D, Rogg M, Woidy M, Eikrem O, Wanner N, Gambardella J, Laufer SD, Haas F, Wong MN, Dumoulin B, Rischke P, Mühlig AK, Sachs W, von Cossel K, Schulz K, Muschol N, Gersting SW, Muntau AC, Kretz O, Hahn O, Rinschen MM, Mauer M, Bork T, Grahammer F, Liang W, Eierhoff T, Römer W, Hansen A, Meyer-Schwesinger C, Iaccarino G, Tøndel C, Marti HP, Najafian B, Puelles VG, Schell C, Huber TB.  J Clin Invest. 2023 Apr 4:e157782.
7.
Mühlig AK, Oh J, Huber TB.  Kidney Int. 2023 Mar;103(3):464-466. 
8.
Mühlig AK, Steingröver J, Heidelbach HS, Wingerath M, Sachs W, Hermans-Borgmeyer I, Meyer-Schwesinger C, Choi HY, Lim BJ, Patry C, Hoffmann GF, Endlich N, Bracke K, Weiß M, Guse AH, Lassé M, Rinschen M, Braun F, Huber TB, Puelles VG, Schmitt CP, Oh J. Kidney Int. 2022 Mar 7:S0085-2538(22)00175-2.
9.

Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H.
Mühlig AK, Keir LS, Abt JC, Heidelbach HS, Horton R, Welsh GI, Meyer-Schwesinger C, Licht C, Coward RJ, Fester L, Saleem MA, Oh J. Front Immunol. 2020 Aug 14;11:1833. 
10.
Mühlig AK, Lee JY, Kemper MJ, Kronbichler A, Yang JW, Lee JM, Shin JI, Oh J. J Clin Med. 2019 Jun 16;8(6):860. 

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Musal

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  • Mailadresse: Isabell Musal
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  • Datum + Kategorie: Technican

Naira Moussa

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  • Mailadresse: Naira Moussa
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  • Datum + Kategorie: PhD student

Neuber

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  • Mailadresse: Christiane Neuber, PhD
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  • Datum + Kategorie: Research Coordination

Nosi

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  • Mailadresse: Vladimir Nosi, PhD
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  • Datum + Kategorie: Post Doc

Obser

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  • Mailadresse: Anja Obser
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  • Datum + Kategorie: Technician

Omid

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  • Mailadresse: Tuba Banu Omid
  • Datum + Kategorie: MD student

Quaas

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  • Mailadresse: Josephine Quaas
  • Datum + Kategorie: MD student

Rövenstrunk

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  • Mailadresse: Götz Rövenstrunk
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  • Datum + Kategorie: MD student

Schaper

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  • Mailadresse: Melanie Schaper
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  • Datum + Kategorie: Technician

Schepke

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  • Mailadresse: Emily Schepke
  • Datum + Kategorie: MD student

Schmidt-Lauber

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  • Mailadresse: Christian Schmidt-Lauber, MD
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  • Datum + Kategorie: Research Group Leader

Christian Schmidt-Lauber

Research Group for Epidemiology and Clinical Nephrology

Mission Statement

“Understanding the epidemiology and complex burden of progressive kidney disease”

— Dr. med. Christian Schmidt-Lauber

Team Members

Research

Kidney diseases pose a significant challenge to global health, explained by the high prevalence and the debilitating consequences on various other organs associated with chronic kidney disease (CKD). However, understanding is evolving that acute kidney injury (AKI), which has conventionally been seen as a transient occurrence, also significantly contributes to long-standing adverse effects on multiple organs, progression of CKD, and the increased long-term mortality. As such, AKI aligns with traditional risk factors for progressive kidney disease, such as hypertension and diabetes. These somatic risk factors are accompanied by demographic and socioeconomic determinants as well as an increasing set of medical treatments influencing kidney diseases or their risk factors.

Our group aims to better understand this complex web of disease modifiers within the trajectory of kidney diseases, their consequences, as well as hypertension, as one of the major somatic risk factors. Additionally, we try to elucidate the underlying role of inflammation, which is emerging as a major pathophysiological component within the kidney disease trajectory. Our work includes a broad set of epidemiological strategies and methods and is performed on large population-based studies (Hamburg City Health Study), AKI and CKD cohort studies (Hamburg and European Renal Omics Bank), as well as overarching nationwide German and Danish registries. This undertaking is conducted with the support of national and international collaborating partners.

Dr. med. Christian Schmidt-Lauber

Junior Group Leader

III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE)
Martinistr. 52
20246 Hamburg, Germany

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CV

  • Current Position

     

    since 2024

    Managing attending, III. Department of Medicine, University Medical Center Hamburg-Eppendorf
    since 2024

    Junior group leader supported by the BMBF iSTAR Advanced Clinician Scientist program
    since 2023

    Spokesperson of the Research Alliance of the Hamburg City Health Study
    since 2022

    Attending physician, III. Department of Medicine, University Medical Center Hamburg- Eppendorf, Germany

  • University Training

    2007- 2014

    Medical School, University Münster, Germany
    2014

    Practical training University of California Medical School, Department of Medicine, San Diego, USA

  • Academic qualifications

    2025

    Habilitation at the University of Hamburg

    2025

    Board Certification in Internal Medicine
    2021 - 2020

    Board Certification in Nephrology and Internal Medicine
    2021

    Certification as expert in hypertension (DHL®)
    2019

    Board Certification in Emergency Medicine
    2013

    Dissertation as Doctor of Medicine, University Münster, Germany (summa cum laude)

  • Previous professional career

    Clinical postgraduate education:

    2019 - 2021

    Residency in Nephrology and Internal Medicine, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Germany
    2016

    Visiting Clinician, Department of Nephrology, Yale University, New Haven,USA
    2015 - 2019

    Residency in Nephrology and Internal Medicine, Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürmberg, Germany

    Scientific education:

    2012 - 2015

    Research Fellow, Division of Experimental Nephrology, Department of Internal Medicine D, and Institute of Musculoskeletal Medicine, University Hospital Münster, Germany
    2011 - 2012

    Research Fellow, Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, USA

  • Selected awards and honors

    2024 - 2020

    Dr.-Günther-Sawitzki-Award of the German Society for Hypertension (DHL®)
    2023

    Best Poster Award, German Society of Transplantation (DTG)
    2022

    “Teacher of the year” Award, University Medical Center Hamburg-Eppendorf, Germany
    2015

    Award for the best Medical Thesis, University of Münster, Germany

Selected publications

1.

Prevalence and Characteristics of Chronic Kidney Disease in the Hamburg City Health Study.
Schmidt-Lauber C, Thompson C, Schmidt EA, Klopp A, Alabdo A, Zeller T, Schäfer I, Twerenbold R, Johansen C, Blankenberg S, Huber TB. Nephrol Dial Transplant. 2025 Apr 30:gfaf075. 
2.

Kidney Function and Cerebral Small Vessel Disease.
Heinze M, Schell M, Mayer C, Nägele FL, Petersen M, Alba Schmidt E, Schmidt IM, Cheng B, Huber TB, Thomalla G, Schmidt-Lauber C. Am J Kidney Dis. 2025 Feb 28:S0272-6386(25)00707-3. 
3.

Acute kidney injury predicts mortality in very elderly critically-ill patients.
Alba Schmidt E, De Rosa S, Müller J, Hüsing P, Daniels R, Theile P, Schweingruber N, Kluge S, Huber TB, Roedl K, Schmidt-Lauber C. Eur J Intern Med. 2024 Sep;127:119-125. 
4.

Kidney outcome after mild to moderate COVID-19.
Schmidt-Lauber C, Hänzelmann S, Schunk S, Petersen EL, Alabdo A, Lindenmeyer M, Hausmann F, Kuta P, Renné T, Twerenbold R, Zeller T, Blankenberg S, Fliser D, Huber TB. Nephrol Dial Transplant. 2023 Aug 31;38(9):2031-2040. 
5.

Molecular consequences of SARS-CoV-2 liver tropism.
Wanner N, Andrieux G, Badia-i-Mompel P, Edler C, Pfefferle S, Lindenmeyer M, Schmidt-Lauber C, Czogalla J, Wong MN, Okabayashi Y, Braun F, Lütgehetmann M, Meister E, Lu S, Noriega MLM, Günther T, Grundhoff A, Fischer N, Bräuninger H, Lindner D, Westermann D, Haas F, Roedl K, Kluge S, Addo MM, Huber S, Lohse AW, Reiser J, Ondruschka B, Sperhake JP, Saez-Rodriguez J, Boerries M, Hayek SS, Aepfelbacher M, Scaturro P, Puelles VG, Huber TB. Nat Metab 2022 Mar;4(3):310-319.
6.

Increased rejection rates in kidney transplantations during the COVID-19 pandemic.
Schmidt-Lauber C, Spoden M, Huber TB, Günster C, Grahammer F. Transpl Int. 2021 Dec;34(12):2899-2902. 
7.

Gadolinium-based compounds induce NLRP3-dependent IL-1β production and peritoneal inflammation.
Schmidt-Lauber C, Bossaller L, Abujudeh HH, Vladimer GI, Christ A, Fitzgerald KA, Latz E, Gravallese EM, Marshak-Rothstein A, Kay J. Ann Rheum Dis. 2015 Nov;74(11):2062-9. 

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Schulz

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  • Mailadresse: Jasmin Schulz
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  • Datum + Kategorie: Study nurse

Schulz

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  • Mailadresse: Kristina Schulz, PhD
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  • Datum + Kategorie: Head of Research Management

Schulz

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  • Mailadresse: Katharina Schulz
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  • Datum + Kategorie: Technician

Sendon

  • Tags: S
  • Mailadresse: Pamella Marie Sendon, PhD
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  • Datum + Kategorie: Post Doc

Squiccimarro

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  • Mailadresse: Elena Squiccimarro
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  • Datum + Kategorie: Visiting Scientist

Teubner

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  • Mailadresse: Jan Teubner, MD
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  • Datum + Kategorie: Clinician Scientist

Tiwary

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  • Mailadresse: Vaibhav Tiwary
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  • Datum + Kategorie: Post Doc, PhD

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Campus Research II N25
20246 Hamburg Germany
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