Veerubhotla

  • Tags: V
  • Mailadresse: Abhiram Veerubhotla
  • Datum + Kategorie: MD student

Wagner

  • Tags: W
  • Mailadresse: Maike Wagner
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  • Datum + Kategorie: MD student

Wanner

  • Tags: W
  • Mailadresse: Nicola Wanner, PhD
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  • Datum + Kategorie: LABORATORY HEAD/JUNIOR GROUP LEADER

Nicola Wanner

Laboratory for molecular analysis of kidney development and disease

Mission Statement

“Utilizing the power of epigenetic and transcriptional regulation to understand kidney cells in development and disease”

— Nicola Wanner, PhD

Team Members

Research

©Nicola Wanner

We are using epigenetic and transcriptional profiling, imaging and nanobodies to understand nephrology: From environmental stressors causing disruption in renal development and the impact of epigenetic regulation of nephrogenesis to investigating renal diseases such as glomerulonephritis and the interaction between the immune system and renal cells, we are exploring multiple facets of renal physiology and disease. As members of the CRC 1192, we use nanobody technology to develop novel treatment strategies for kidney diseases.

Nicola Wanner, PhD

III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE)
Martinistr. 52
20246 Hamburg, Germany

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CV

  • Current position

    since 2025 Principal Investigator CRC/TRR 422 Project D1
    since 2020

    Junior group leader/Principal Investigator CRC 1192 Project B5
    since 2017

    Laboratory head, III. Medical Department, University Medical Center Hamburg Eppendorf, Prof. Dr. T.B. Huber

  • University training

    2004 - 2009

    Molecular Medicine at the Albert-Ludwigs University Freiburg im Breisgau, Germany

  • Academic qualifications

    2013 - 2017

    PhD at the University of Freiburg – Spemann Graduate School of Biology and Medicine (summa cum laude)

    2009 - 2017

    Diploma in Molecular Medicine at the University of Freiburg

  • Previous professional career

    2013 - 2017

    Postdoctoral Fellow, Department of Nephrology, University Hospital Freiburg, Germany, Prof. Dr. Tobias B. Huber

  • Selected awards and honors

    2024

    Award of the UKE Foundation
    2014 - 2020

    Rainer-Greger Prize for PhD thesis in Nephrology
    2009 - 2013

    2009 - 2013 PhD Fellowship of the Spemann Graduate School of Biology and Medicine (SGBM)

Selected publications

1.
Kuehl M, Okabayashi Y, Wong MN, Gernhold L, Gut G, Kaiser N, Schwerk M, Gräfe SK, Ma FY, Tanevski J, Schäfer PSL, Mezher S, Sarabia Del Castillo J, Goldbeck-Strieder T, Zolotareva O, Hartung M, Delgado Chaves FM, Klinkert L, Gnirck AC, Spehr M, Fleck D, Joodaki M, Parra V, Shaigan M, Diebold M, Prinz M, Kranz J, Kux JM, Braun F, Kretz O, Wu H, Grahammer F, Heins S, Zimmermann M, Haas F, Kylies D, Wanner N, Czogalla J, Dumoulin B, Zolotarev N, Lindenmeyer M, Karlson P, Nyengaard JR, Sebode M, Weidemann S, Wiech T, Groene HJ, Tomas NM, Meyer-Schwesinger C, Kuppe C, Kramann R, Karras A, Bruneval P, Tharaux PL, Pastene D, Yard B, Schaub JA, McCown PJ, Pyle L, Choi YJ, Yokoo T, Baumbach J, Sáez PJ, Costa I, Turner JE, Hodgin JB, Saez-Rodriguez J, Huber TB, Bjornstad P, Kretzler M, Lenoir O, Nikolic-Paterson DJ, Pelkmans L, Bonn S, Puelles VG. Nature. 2025 Jul 18. doi: 10.1038/s41586-025-09225-2. 
2.

ATP-Gated P2X7-Ion Channel on Kidney-Resident Natural Killer T Cells and Memory T Cells in Intrarenal Inflammation.
Junge M, Liaukouskaya N, Schwarz N, Pinto-Espinoza C, Schaffrath AZ, Rissiek B, Krebs CF, Rattay G, Mittrücker HW, Tomas NM, Nicke A, Haag F, Huber TB, Meyer-Schwesinger C, Koch-Nolte F, Wanner N. J Am Soc Nephrol. 2024 Dec 9. 
3.

Adeno-associated virus-based gene therapy treats inflammatory kidney disease in mice.
Wu G, Liu S, Hagenstein J, Alawi M, Hengel FE, Schaper M, Akyüz N, Liao Z, Wanner N, Tomas NM, Failla AV, Dierlamm J, Körbelin J, Lu S, Huber TB.  J Clin Invest. 2024 Aug 15;134(17):e174722.
4.

Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens.
Kylies D, Zimmermann M, Haas F, Schwerk M, Kuehl M, Brehler M, Czogalla J, Hernandez LC, Konczalla L, Okabayashi Y, Menzel J, Edenhofer I, Mezher S, Aypek H, Dumoulin B, Wu H, Hofmann S, Kretz O, Wanner N, Tomas NM, Krasemann S, Glatzel M, Kuppe C, Kramann R, Banjanin B, Schneider RK, Urbschat C, Arck P, Gagliani N, van Zandvoort M, Wiech T, Grahammer F, Sáez PJ, Wong MN, Bonn S, Huber TB, Puelles VG.  Nat Nanotechnol. 2023 Apr;18(4):336-342. 
5.

Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy
Braun F, Abed A, Sellung D, Rogg M, Woidy M, Eikrem O, Wanner N, Gambardella J, Laufer SD, Haas F, Wong MN, Dumoulin B, Rischke P, Mühlig A, Sachs W, von Cossel K, Schulz K, Muschol N, Gersting SW, Muntau AC, Kretz O, Hahn O, Rinschen MM, Mauer M, Bork T, Grahammer F, Liang W, Eierhoff T, Römer W, Hansen A, Meyer-Schwesinger C, Iaccarino G, Tøndel C, Marti HP, Najafian B, Puelles VG, Schell C, Huber TB. J Clin Invest. 2023 Jun 1;133(11):e157782. 
6.

Molecular consequences of SARS-CoV-2 liver tropism.
Wanner N, Andrieux G, Badia-i-Mompel P, Edler C, Pfefferle S, Lindenmeyer M, Schmidt-Lauber C, Czogalla J, Wong MN, Okabayashi Y, Braun F, Lütgehetmann M, Meister E, Lu S, Noriega MLM, Günther T, Grundhoff A, Fischer N, Bräuninger H, Lindner D, Westermann D, Haas F, Roedl K, Kluge S, Addo MM, Huber S, Lohse AW, Reiser J, Ondruschka B, Sperhake JP, Saez-Rodriguez J, Boerries M, Hayek SS, Aepfelbacher M, Scaturro P, Puelles VG, Huber TB. Nat Metab 2022 Mar;4(3):310-319.
7.

Multiorgan and Renal Tropism of SARS-CoV-2.
Puelles VG, Lütgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, Chilla S, Heinemann A, Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schröder AS, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Kluge S, Pueschel K, Aepfelbacher M, Huber TB. N Engl J Med. 2020 Aug 6;383(6):590-592.
8.

mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans.
Puelles VG, van der Wolde JW, Wanner N, Scheppach MW, Cullen-McEwen LA, Bork T, Lindenmeyer MT, Gernhold L, Wong MN, Braun F, Cohen CD, Kett MM, Kuppe C, Kramann R, Saritas T, van Roeyen CR, Moeller MJ, Tribolet L, Rebello R, Sun YB, Li J, Müller-Newen G, Hughson MD, Hoy WE, Person F, Wiech T, Ricardo SD, Kerr PG, Denton KM, Furic L, Huber TB, Nikolic-Paterson DJ, Bertram JF. JCI Insight. 2019 Sep 19;4(18):e99271.
9.

DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.
Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles VG, Rahman RU, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek ME, Romano T, Moritz KM, Boerries M, Busch H, Bonn S, Little MH, Bechtel-Walz W, Huber TB. J Am Soc Nephrol. 2019 Jan;30(1):63-78.
10.

Unraveling the role of podocyte turnover in glomerular aging and injury.
Wanner N, Hartleben B, Herbach N, Goedel M, Stickel N, Zeiser R, Walz G, Moeller MJ, Grahammer F, Huber TB. J Am Soc Nephrol. 2014 Apr;25(4):707-16.

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Wöhner

  • Tags: W
  • Mailadresse: Birte Wöhner, MD
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  • Datum + Kategorie: Clinician Scientist

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Zahner

  • Tags: Z
  • Mailadresse: Gunther Zahner, PhD
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  • Datum + Kategorie: Laboratory Head/Group Leader

Gunther Zahner

Team

Mission Statement

“Understandung antibody-mediated kidney disase to investigate target specific therapeutical options”

— Gunther Zahner, PhD

Team Members

Research

@ Tomas et al. 2022, Kidney International

Currently two Phospholipase A2 receptor (PLA2R)-specific experimental membranous nephritis models are established. In the one with mice, the complete human PLA2R is expressed specifically in podocytes, leading to the spontaneous development of PLA2R titer very early after birth. Consequently, granular immune complexes (green) and subepithelial electron-dense deposits are generated followed by severe proteinuria six weeks after birth (see graph). In a second model, a chimeric PLA2R consisting of human CysR-CTLD1, the most immunogenic part, and murine CTLD2-CTLD8, is specifically expressed in podocytes. This chimeric PLA2R expression is tolerated and therefore suitable for directed active immunisation using huPLA2R protein. After active immunisation, membranous nephropathy develops after 6 to 10 weeks including all expected features of the disease.

Using these models, we investigate the course of pathophysiology from disease initiation up to the end point of severe proteinuria including the still controversially discussed role of the complement system. Furthermore, both models are currently used to investigate highly specific therapies of different settings.

Gunther Zahner, PhD

III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE)
Martinistr. 52
20246 Hamburg, Germany

CV

  • Current Position

    since 2011

    Senior Physician, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Prof. Dr. Tobias B. Huber

  • University Training

    1984 - 1989

    Study of Biology, University of Stuttgart, Germany

  • Academic qualifications

     1990 - 1994 PhD Thesis, Institute of Biology, University of Stuttgart, docotoral adviser: Prof. Dr. Kurt Köhler

  • Previous professional career

    Scientific postgraduate education:

    1995 - 2010

    Post doctoral fellow, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Prof. Dr. Rolf A.K. Stahl

  • Selected awards and honors

Selected publications

1.
Zahner G, Dehde S, Seifert L, Huang M, Kretz O, Huber TB, Tomas NM.  Kidney Int. 2025 Dec;108(6):1179-1183. 
2.
Hengel FE, Dehde S, Lassé M, Zahner G, Seifert L, Schnarre A, Kretz O, Demir F, Pinnschmidt HO, Grahammer F, Lucas R, Mehner LM, Zimmermann T, Billing AM, Oh J, Mitrotti A, Pontrelli P, Debiec H, Dossier C, Colucci M, Emma F, Smoyer WE, Weins A, Schaefer F, Alachkar N, Diemert A, Hogan J, Hoxha E, Wiech T, Rinschen MM, Ronco P, Vivarelli M, Gesualdo L, Tomas NM, Huber TB; International Society of Glomerular Disease. N Engl J Med. 2024 Aug 1;391(5):422-433.
3.
Seifert L, Riecken K, Zahner G, Hambach J, Hagenstein J, Dubberke G, Huber TB, Koch-Nolte F, Fehse B, Tomas NM. Kidney Int. 2024 Apr;105(4):886-889.
4.
Tomas NM, Schnarre A, Dehde S, Lucas R, Hermans-Borgmeyer I, Kretz O, Koellner SMS, Wiech T, Koch-Nolte F, Seifert L, Huber TB, Zahner G. Kidney Int. 2023 Nov;104(5):916-928. 
5.
Seifert L, Zahner G, Meyer-Schwesinger C, Hickstein N, Dehde S, Wulf S, Köllner SMS, Lucas R, Kylies D, Froembling S, Zielinski S, Kretz O, Borodovsky A, Biniaminov S, Wang Y, Cheng H, Koch-Nolte F, Zipfel PF, Hopfer H, Puelles VG, Panzer U, Huber TB, Wiech T, Tomas NM.  Nat Commun. 2023 Jan 28;14(1):473. 
6.
Tomas NM, Dehde S, Meyer-Schwesinger C, Huang M, Hermans-Borgmeyer I, Maybaum J, Lucas R, von der Heide JL, Kretz O, Köllner SMS, Seifert L, Huber TB, Zahner G.  Kidney Int. 2023 Feb;103(2):297-303.
7.
Köllner SMS, Seifert L, Zahner G, Tomas NM. Front Immunol. 2022 Feb 3;13:822508.
8.
Meyer-Schwesinger C, Tomas NM,  Dehde S, Seifert L, Hermans-Borgmeyer I, Wiech T, Koch-Nolte F, Huber TB, Zahner G. Kidney Int. 2020 May;97(5):913-919.
9.
Reinhard L, Zahner G, Menzel S, Koch-Nolte F, Stahl RAK, Hoxha E. J Am Soc Nephrol. 2020 Jan;31(1):197-207.

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Zhu Yifan

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  • Mailadresse: Yifan Zhu
  • Datum + Kategorie: MD/PhD Student

Zolotarev

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  • Mailadresse: Nikolay Zolotarev, PhD
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  • Datum + Kategorie: Post Doc

Martinistraße 52
Campus Research II N25
20246 Hamburg Germany
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