Hengel FE, et al., NEJM. 2024

An international study using a novel assay technique reliably detected anti-nephrin autoantibodies in up to 90% of idiopathic nephrotic syndrome. The study is based on serum/plasma analysis of samples from a multi-center cohort of 357 adults with various glomerular diseases and 192 children with idiopathic nephrotic syndrome, plus 117 healthy controls. The circulating antinephrin autoantibodies were common in patients with minimal change disease or idiopathic nephrotic syndrome and appeared to be markers of disease activity. Their binding at the slit diaphragm induced podocyte dysfunction and nephrotic syndrome, which highlights their pathophysiological significance. 

 

This new research, presented May 25 at the 61^st ERA Congress with simultaneous publication in the New England Journal of Medicine.

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